Dmitry V. Demchuk, Olga I. Adaeva, Dmitry V. Tsyganov, Darina I. Nasyrova, Roman A. Dolotov, Еgor А. Muravsky, Alexander E. Varakutin, Alexander V. Samet, Victor V. Semenov
{"title":"通过羰基取代的多烷氧基苯的拜尔-维利格重排从欧芹籽提取物中合成辅酶 Q10 代谢物的甲氧基类似物","authors":"Dmitry V. Demchuk, Olga I. Adaeva, Dmitry V. Tsyganov, Darina I. Nasyrova, Roman A. Dolotov, Еgor А. Muravsky, Alexander E. Varakutin, Alexander V. Samet, Victor V. Semenov","doi":"10.1055/s-0043-1775368","DOIUrl":null,"url":null,"abstract":"<p>Based on the parsley seed main component, apiol, efficient approach to polymethoxyquinone C<sub>3</sub>- and C<sub>4</sub>-acids was developed. The key step of this approach is Baeyer–Villiger rearrangement of carbonyl-substituted polyalkoxybenzenes derived from parsley seed extracts. These acids are the MeO-analogues of natural antioxidants – metabolites of ubiquinone and idebenone. Due to antioxidant properties, they are the potential therapeutic candidates for the treatment of mitochondrial dysfunction.</p> ","PeriodicalId":501298,"journal":{"name":"Synthesis","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of Methoxy Analogues of Coenzyme Q10 Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes\",\"authors\":\"Dmitry V. Demchuk, Olga I. Adaeva, Dmitry V. Tsyganov, Darina I. Nasyrova, Roman A. Dolotov, Еgor А. Muravsky, Alexander E. Varakutin, Alexander V. Samet, Victor V. Semenov\",\"doi\":\"10.1055/s-0043-1775368\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Based on the parsley seed main component, apiol, efficient approach to polymethoxyquinone C<sub>3</sub>- and C<sub>4</sub>-acids was developed. The key step of this approach is Baeyer–Villiger rearrangement of carbonyl-substituted polyalkoxybenzenes derived from parsley seed extracts. These acids are the MeO-analogues of natural antioxidants – metabolites of ubiquinone and idebenone. Due to antioxidant properties, they are the potential therapeutic candidates for the treatment of mitochondrial dysfunction.</p> \",\"PeriodicalId\":501298,\"journal\":{\"name\":\"Synthesis\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synthesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/s-0043-1775368\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthesis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0043-1775368","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis of Methoxy Analogues of Coenzyme Q10 Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes
Based on the parsley seed main component, apiol, efficient approach to polymethoxyquinone C3- and C4-acids was developed. The key step of this approach is Baeyer–Villiger rearrangement of carbonyl-substituted polyalkoxybenzenes derived from parsley seed extracts. These acids are the MeO-analogues of natural antioxidants – metabolites of ubiquinone and idebenone. Due to antioxidant properties, they are the potential therapeutic candidates for the treatment of mitochondrial dysfunction.
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