Amir Hossein Vakilzadeh, Amirhossein Bagheri Sarvestani, Reza Kamali, Kourosh Javaherdeh
{"title":"往复式血液泵的数值模拟:阀门运动和泄漏流量对溶血性能的影响","authors":"Amir Hossein Vakilzadeh, Amirhossein Bagheri Sarvestani, Reza Kamali, Kourosh Javaherdeh","doi":"10.1007/s40997-024-00784-9","DOIUrl":null,"url":null,"abstract":"<p>The left ventricular assist device (LVAD) is a blood pump that boosts the pumping ability of the bottom left chamber of the heart in patients with advanced stage of heart failure. This study aims to present a detailed investigation into the hemolytic characteristics associated with an LVAD, while scrutinizing the impact of valves on blood damage in a reciprocating blood pump. To this end, a numerical approach is utilized to explore the effect of valves movement and leakage flow as the two critical causes of red blood cell damage (hemolysis) by capturing the full range of the valve motion. To predict both blood flow and the hemolysis index, corresponding time-dependent nonlinear partial differential equations are integrated into the governing formulation system. The fluid dynamic characteristics are derived from the Navier–Stokes equations, while the degree of hemolysis is determined by incorporating two additional scalar transport equations using an Eulerian transport method. To simulate valves closure, we consider different methods namely, dynamic mesh technique, viscosity valve closure model and the combination of both. The findings reveal that the hemolysis index is minimum at the inlet region and acquires its maximum value at the valves and clearance subdomains. Moreover, the results depict a favorable reduction in the hemolysis index through a simultaneous increase in frequency and decrease at a specific Reynolds number. It is observed that valves movement and valves leakage flow lead to a sensible one and two order of magnitude increase in the hemolysis index, respectively.</p>","PeriodicalId":49063,"journal":{"name":"Iranian Journal of Science and Technology-Transactions of Mechanical Engineering","volume":"53 1","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Numerical Simulation of Reciprocating Blood Pump: Effect of Valve Movement and Leakage Flow on Hemolytic Performance\",\"authors\":\"Amir Hossein Vakilzadeh, Amirhossein Bagheri Sarvestani, Reza Kamali, Kourosh Javaherdeh\",\"doi\":\"10.1007/s40997-024-00784-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The left ventricular assist device (LVAD) is a blood pump that boosts the pumping ability of the bottom left chamber of the heart in patients with advanced stage of heart failure. This study aims to present a detailed investigation into the hemolytic characteristics associated with an LVAD, while scrutinizing the impact of valves on blood damage in a reciprocating blood pump. To this end, a numerical approach is utilized to explore the effect of valves movement and leakage flow as the two critical causes of red blood cell damage (hemolysis) by capturing the full range of the valve motion. To predict both blood flow and the hemolysis index, corresponding time-dependent nonlinear partial differential equations are integrated into the governing formulation system. The fluid dynamic characteristics are derived from the Navier–Stokes equations, while the degree of hemolysis is determined by incorporating two additional scalar transport equations using an Eulerian transport method. To simulate valves closure, we consider different methods namely, dynamic mesh technique, viscosity valve closure model and the combination of both. The findings reveal that the hemolysis index is minimum at the inlet region and acquires its maximum value at the valves and clearance subdomains. Moreover, the results depict a favorable reduction in the hemolysis index through a simultaneous increase in frequency and decrease at a specific Reynolds number. It is observed that valves movement and valves leakage flow lead to a sensible one and two order of magnitude increase in the hemolysis index, respectively.</p>\",\"PeriodicalId\":49063,\"journal\":{\"name\":\"Iranian Journal of Science and Technology-Transactions of Mechanical Engineering\",\"volume\":\"53 1\",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Science and Technology-Transactions of Mechanical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1007/s40997-024-00784-9\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, MECHANICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Science and Technology-Transactions of Mechanical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s40997-024-00784-9","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, MECHANICAL","Score":null,"Total":0}
A Numerical Simulation of Reciprocating Blood Pump: Effect of Valve Movement and Leakage Flow on Hemolytic Performance
The left ventricular assist device (LVAD) is a blood pump that boosts the pumping ability of the bottom left chamber of the heart in patients with advanced stage of heart failure. This study aims to present a detailed investigation into the hemolytic characteristics associated with an LVAD, while scrutinizing the impact of valves on blood damage in a reciprocating blood pump. To this end, a numerical approach is utilized to explore the effect of valves movement and leakage flow as the two critical causes of red blood cell damage (hemolysis) by capturing the full range of the valve motion. To predict both blood flow and the hemolysis index, corresponding time-dependent nonlinear partial differential equations are integrated into the governing formulation system. The fluid dynamic characteristics are derived from the Navier–Stokes equations, while the degree of hemolysis is determined by incorporating two additional scalar transport equations using an Eulerian transport method. To simulate valves closure, we consider different methods namely, dynamic mesh technique, viscosity valve closure model and the combination of both. The findings reveal that the hemolysis index is minimum at the inlet region and acquires its maximum value at the valves and clearance subdomains. Moreover, the results depict a favorable reduction in the hemolysis index through a simultaneous increase in frequency and decrease at a specific Reynolds number. It is observed that valves movement and valves leakage flow lead to a sensible one and two order of magnitude increase in the hemolysis index, respectively.
期刊介绍:
Transactions of Mechanical Engineering is to foster the growth of scientific research in all branches of mechanical engineering and its related grounds and to provide a medium by means of which the fruits of these researches may be brought to the attentionof the world’s scientific communities. The journal has the focus on the frontier topics in the theoretical, mathematical, numerical, experimental and scientific developments in mechanical engineering as well
as applications of established techniques to new domains in various mechanical engineering disciplines such as: Solid Mechanics, Kinematics, Dynamics Vibration and Control, Fluids Mechanics, Thermodynamics and Heat Transfer, Energy and Environment, Computational Mechanics, Bio Micro and Nano Mechanics and Design and Materials Engineering & Manufacturing.
The editors will welcome papers from all professors and researchers from universities, research centers,
organizations, companies and industries from all over the world in the hope that this will advance the scientific standards of the journal and provide a channel of communication between Iranian Scholars and their colleague in other parts of the world.