Et3N 催化的 β-氧代丙烯酰胺与 2-氧代丙二酸二乙酯的[3 + 2]环化反应：轻松获得噁唑烷-4-酮衍生物

IF 1.4 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Letters Pub Date : 2024-07-02 DOI:10.1093/chemle/upae116

Lingang Wu, Baochuan Guan, Zhaoxue Wang, Lei Xie

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引用次数: 0

摘要

在 NEt3 催化下，开发出了一种在温和反应条件下进行 β-氧代丙烯酰胺与 2-氧代丙二酸二乙酯[3 + 2]环化反应的有效新方法。这种方法提供了合成噁唑烷-4-酮衍生物的直接途径，产率在 58% 至 76% 之间。该工艺的显著特点是原子效率高、操作简单。

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Et3N-catalyzed [3 + 2] annulation reaction of β-oxo-acrylamides with diethyl 2-oxomalonates: facile access to oxazolidin-4-one derivatives

A new and effective method for the [3 + 2] annulation of β-oxo-acrylamides with diethyl 2-oxomalonate, catalyzed by NEt3, has been developed to be carried out under mild reaction conditions. This approach offers a direct route to synthesize oxazolidin-4-one derivatives with yields ranging from 58% to 76%. The process is notable for being highly atom-efficient and operationally simple.

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来源期刊

Chemistry Letters 化学-化学综合

CiteScore

3.00

自引率

6.20%

发文量

260

审稿时长

1.2 months

期刊介绍： Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry