有益突变的积累和向泊松过程的收敛

Nantawat Udomchatpitak, Jason Schweinsberg
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引用次数: 0

摘要

我们考虑了一个具有固定规模 $N$ 的种群模型,该种群以恒定的速率 $\mu_N$ 无限供应有益突变。每个个体以 1 的速率死亡,并被随机选择的个体所取代,该个体的概率与其适合度成正比。我们证明,当 $\mu_N \ll 1/(N \logN)$ 和 $N^{-\eta} \ll s_N \ll 1$ 时,对于某些 $\eta < 1$,大量有益突变同时出现在种群中,相互竞争,然而有益突变的固定时间在时间缩放之后,会收敛到泊松过程的时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Accumulation of Beneficial Mutations and Convergence to a Poisson Process
We consider a model of a population with fixed size $N$, which is subjected to an unlimited supply of beneficial mutations at a constant rate $\mu_N$. Individuals with $k$ beneficial mutations have the fitness $(1+s_N)^k$. Each individual dies at rate 1 and is replaced by a random individual chosen with probability proportional to its fitness. We show that when $\mu_N \ll 1/(N \log N)$ and $N^{-\eta} \ll s_N \ll 1$ for some $\eta < 1$, large numbers of beneficial mutations are present in the population at the same time, competing against each other, yet the fixation times of beneficial mutations, after a time scaling, converge to the times of a Poisson process.
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