静脉注射利多卡因剂量对小儿扁桃体切除术苏醒后疼痛的影响:随机试验

Yang Hu, Ming Cheng Du, Yi Chen, Xiang Long, Jing Jing Jiang, yuan gong
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引用次数: 0

摘要

我们研究了静脉注射利多卡因以剂量依赖的方式减轻苏醒时疼痛的潜力,目的是确定利多卡因的中位有效剂量,对象是在宜昌市中心人民医院接受扁桃体切除术(带或不带腺样体切除术)的 200 名 3-12 岁儿童(美国麻醉医师协会体能状态 I-II)。患者被随机分为四个剂量组(A-D:分别为 0.0、1.0、1.5 和 2.0 mg/kg),并接受相同的麻醉诱导和维持方案。主要结果是苏醒时的疼痛,次要结果包括苏醒后 1、4、12 和 24 小时的疼痛评分;喉痉挛、支气管痉挛或围手术期呼吸困难的发生率;以及拔管时间。术中心脏事件被归类为安全事件。我们的研究结果表明,静脉注射利多卡因能有效减轻苏醒时的疼痛,有效剂量中位数为 1.75 毫克/千克。A组和D组之间存在显著差异(P≤0.001)。没有观察到喉痉挛、支气管痉挛或围手术期喘息的情况。此外,组间在拔管时间上存在明显差异(P ≤ 0.05)。总之,我们的研究表明,利多卡因剂量依赖性地减轻了扁桃体切除术合并或不合并腺样体切除术患儿苏醒时的疼痛,且未出现严重不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of intravenous lidocaine dose on pain upon awakening in pediatric tonsillectomy: A randomized trial
We investigated the potential of intravenous lidocaine to reduce pain on awakening in a dose-dependent manner and aimed to determine the median effective dose of lidocaine in 200 children aged 3–12 years (American Society of Anesthesiologists physical status I–II) who underwent elective tonsillectomy with or without adenoidectomy at Yichang Central People’s Hospital. The patients were randomized into four dose groups (A–D: 0.0, 1.0, 1.5, and 2.0 mg/kg, respectively), and they underwent the same anesthetic induction and maintenance protocols. The primary outcome was pain on awakening, while secondary outcomes included pain scores at 1, 4, 12, and 24 h after awakening; incidences of laryngospasm, bronchospasm, or perioperative stridor; and time to extubation. Intraoperative cardiac events were classified as safety events. Our findings indicated that intravenous lidocaine dose-dependently reduced pain on awakening, with the median effective dose being 1.75 mg/kg. Significant differences were observed between groups A and D (P ≤ 0.001). No incidents of laryngospasm, bronchospasm, or perioperative stridor were observed. Furthermore, there were significant between-group differences in time to extubation (P ≤ 0.05). In conclusion, our study demonstrated that lidocaine dose-dependently reduced pain on awakening in children undergoing tonsillectomy with or without adenoidectomy, with no severe adverse events.
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