壳聚糖/生物玻璃纳米复合材料用于骨组织工程和再生医学：前景广阔的生物材料概述

IF 1.7 3区化学 Q3 CHEMISTRY, ORGANIC

Current Organic Chemistry Pub Date : 2024-06-26 DOI:10.2174/0113852728314706240529052535

Khashayar Khodaverdi, Seyed Morteza Naghib, M.R. Mozafari

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引用次数: 0

摘要

:生物活性玻璃（BG）作为骨再生生物材料具有巨大潜力。壳聚糖增强了生物活性玻璃的生物特性。壳聚糖是唯一常用的天然多糖，可通过化学变化达到各种目的和作用。壳聚糖生物活性玻璃（BG）纳米颗粒和微颗粒形成的复合材料被应用于这一领域。结合生物活性玻璃可增强最终产品的机械特性、生物活性和再生能力。研究表明，壳聚糖/BG 复合材料可促进血管生成、细胞粘附和增殖。生物玻璃可改善生物矿化，促进成骨细胞形成细胞外基质。目前的研究结果表明，壳聚糖-玻璃纳米纤维复合材料可增强抗菌能力和骨传导性。本综述探讨了创建壳聚糖基工程材料的新技术，以及即将面临的困难和前景。

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Chitosan/Bioglass Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: An Overview of Promising Biomaterials

: Bioactive glass (BG) shows great potential as a biomaterial for bone regeneration. Chitosan enhances the biological characteristics of BG. Chitosan is the sole commonly utilized natural polysaccharide that may be chemically altered for various purposes and roles. Composite materials formed by combining chitosan bioactive glass (BG) nanoparticles and microparticles are used in this context. Integrating bioactive glasses enhances the mechanical characteristics, bioactivity, and regenerative capacity of the end product. Research indicates that chitosan/BG composites enhance angiogenesis, cell adhesion, and proliferation. Bioglass improves biomineralization and boosts bone extracellular matrix formation by osteoblasts. The current findings demonstrate that the chitosan-glass nanofiber composites can enhance both antibacterial capabilities and bone conductivity. This review examines novel techniques for creating chitosan-based materials for engineering purposes, as well as upcoming difficulties and outlooks.

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来源期刊

Current Organic Chemistry 化学-有机化学

CiteScore

3.70

自引率

7.70%

发文量

审稿时长

1 months

期刊介绍： Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.