确定生命阈值需要对组装指数进行实验测量

Sara I. Walker, Cole Mathis, Stuart Marshall, Leroy Cronin
{"title":"确定生命阈值需要对组装指数进行实验测量","authors":"Sara I. Walker, Cole Mathis, Stuart Marshall, Leroy Cronin","doi":"arxiv-2406.06826","DOIUrl":null,"url":null,"abstract":"Assembly Theory (AT) was developed to help distinguish living from non-living\nsystems. The theory is simple as it posits that the amount of selection or\nAssembly is a function of the number of complex objects where their complexity\ncan be objectively determined using assembly indices. The assembly index of a\ngiven object relates to the number of recursive joining operations required to\nbuild that object and can be not only rigorously defined mathematically but can\nbe experimentally measured. In pervious work we outlined the theoretical basis,\nbut also extensive experimental measurements that demonstrated the predictive\npower of AT. These measurements showed that is a threshold in assembly indices\nfor organic molecules whereby abiotic chemical systems could not randomly\nproduce molecules with an assembly index greater or equal than 15. In a recent\npaper by Hazen et al [1] the authors not only confused the concept of AT with\nthe algorithms used to calculate assembly indices, but also attempted to\nfalsify AT by calculating theoretical assembly indices for objects made from\ninorganic building blocks. A fundamental misunderstanding made by the authors\nis that the threshold is a requirement of the theory, rather than experimental\nobservation. This means that exploration of inorganic assembly indices\nsimilarly requires an experimental observation, correlated with the theoretical\ncalculations. Then and only then can the exploration of complex inorganic\nmolecules be done using AT and the threshold for living systems, as expressed\nwith such building blocks, be determined. Since Hazen et al.[1] present no\nexperimental measurements of assembly theory, their analysis is not\nfalsifiable.","PeriodicalId":501219,"journal":{"name":"arXiv - QuanBio - Other Quantitative Biology","volume":"9 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Experimental Measurement of Assembly Indices are Required to Determine The Threshold for Life\",\"authors\":\"Sara I. Walker, Cole Mathis, Stuart Marshall, Leroy Cronin\",\"doi\":\"arxiv-2406.06826\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Assembly Theory (AT) was developed to help distinguish living from non-living\\nsystems. The theory is simple as it posits that the amount of selection or\\nAssembly is a function of the number of complex objects where their complexity\\ncan be objectively determined using assembly indices. The assembly index of a\\ngiven object relates to the number of recursive joining operations required to\\nbuild that object and can be not only rigorously defined mathematically but can\\nbe experimentally measured. In pervious work we outlined the theoretical basis,\\nbut also extensive experimental measurements that demonstrated the predictive\\npower of AT. These measurements showed that is a threshold in assembly indices\\nfor organic molecules whereby abiotic chemical systems could not randomly\\nproduce molecules with an assembly index greater or equal than 15. In a recent\\npaper by Hazen et al [1] the authors not only confused the concept of AT with\\nthe algorithms used to calculate assembly indices, but also attempted to\\nfalsify AT by calculating theoretical assembly indices for objects made from\\ninorganic building blocks. A fundamental misunderstanding made by the authors\\nis that the threshold is a requirement of the theory, rather than experimental\\nobservation. This means that exploration of inorganic assembly indices\\nsimilarly requires an experimental observation, correlated with the theoretical\\ncalculations. Then and only then can the exploration of complex inorganic\\nmolecules be done using AT and the threshold for living systems, as expressed\\nwith such building blocks, be determined. Since Hazen et al.[1] present no\\nexperimental measurements of assembly theory, their analysis is not\\nfalsifiable.\",\"PeriodicalId\":501219,\"journal\":{\"name\":\"arXiv - QuanBio - Other Quantitative Biology\",\"volume\":\"9 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"arXiv - QuanBio - Other Quantitative Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/arxiv-2406.06826\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Other Quantitative Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2406.06826","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

集合理论(AT)的提出有助于区分生命系统和非生命系统。该理论非常简单,它认为选择或组装的数量是复杂物体数量的函数,而复杂性可以通过组装指数客观地确定。某个对象的装配指数与构建该对象所需的递归连接操作次数有关,它不仅可以用数学方法严格定义,还可以用实验方法测量。在之前的工作中,我们不仅概述了 AT 的理论基础,还进行了大量实验测量,证明了 AT 的预测能力。这些测量结果表明,有机分子的装配指数有一个临界值,非生物化学系统不可能随机产生装配指数大于或等于 15 的分子。在 Hazen 等人最近发表的一篇论文[1]中,作者不仅混淆了组装指数的概念和用于计算组装指数的算法,而且还试图通过计算由无机构件构成的物体的理论组装指数来伪造组装指数。作者的一个基本误解是,阈值是理论的要求,而不是实验观察的要求。这意味着对无机组装指数的探索同样需要与理论计算相关联的实验观察。然后,也只有这样,才能利用 AT 技术探索复杂的无机分子,并确定用此类构件表示的生命系统的阈值。由于 Hazen 等人[1]没有提出装配理论的实验测量结果,因此他们的分析无法证伪。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Experimental Measurement of Assembly Indices are Required to Determine The Threshold for Life
Assembly Theory (AT) was developed to help distinguish living from non-living systems. The theory is simple as it posits that the amount of selection or Assembly is a function of the number of complex objects where their complexity can be objectively determined using assembly indices. The assembly index of a given object relates to the number of recursive joining operations required to build that object and can be not only rigorously defined mathematically but can be experimentally measured. In pervious work we outlined the theoretical basis, but also extensive experimental measurements that demonstrated the predictive power of AT. These measurements showed that is a threshold in assembly indices for organic molecules whereby abiotic chemical systems could not randomly produce molecules with an assembly index greater or equal than 15. In a recent paper by Hazen et al [1] the authors not only confused the concept of AT with the algorithms used to calculate assembly indices, but also attempted to falsify AT by calculating theoretical assembly indices for objects made from inorganic building blocks. A fundamental misunderstanding made by the authors is that the threshold is a requirement of the theory, rather than experimental observation. This means that exploration of inorganic assembly indices similarly requires an experimental observation, correlated with the theoretical calculations. Then and only then can the exploration of complex inorganic molecules be done using AT and the threshold for living systems, as expressed with such building blocks, be determined. Since Hazen et al.[1] present no experimental measurements of assembly theory, their analysis is not falsifiable.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信