含有手性酰胺基团的对称元取代聚(二苯基乙炔)的合成及其在高效液相色谱手性固定相中的应用

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Sanhanut Kesornsit, Tsuyoshi Taniguchi, Mai Nozaki, Tatsuya Nishimura, Katsuhiro Maeda
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引用次数: 0

摘要

通过使(R)-1-苯基乙胺与含羧基的前体聚合物反应,合成了一种带有手性酰胺基团的对称元取代聚(二苯基乙炔),该前体聚合物是通过使用改良的基于钼(V)的催化系统聚合相应的含酯二苯基乙炔,然后进行水解而得到的。该聚合物在溶剂中热退火后形成单手螺旋构象。当聚合物用作高效液相色谱手性固定相时,研究了热退火前后聚合物的手性识别能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis of a Symmetrically meta-Substituted Poly(diphenylacetylene) Bearing Chiral Amide Groups and Its Application as a Chiral Stationary Phase for HPLC
A symmetrically meta-substituted poly(diphenylacetylene) bearing chiral amide groups was synthesized by reacting (R)-1-phenylethylamine with a carboxy-group-containing precursor polymer, which was obtained by polymerizing the corresponding ester-containing diphenylacetylene using a modified Mo(V)-based catalytic system followed by hydrolysis. The polymer formed a one-handed helical conformation when thermally annealed in a solvent. The chiral recognition ability of the polymer before and after thermal annealing was investigated when used as a chiral stationary phase for high-performance liquid chromatography.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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