曲妥珠单抗-德鲁司康：将 HER2 重新定义为与肿瘤无关的生物标记物。

IF 4.4 3区医学 Q2 ONCOLOGY

Targeted Oncology Pub Date : 2024-09-01 Epub Date: 2024-07-04 DOI:10.1007/s11523-024-01079-4

Joseph Zouein, Elias Karam, John H Strickler, Hampig Raphael Kourie

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引用次数: 0

摘要

曲妥珠单抗德鲁司坦（T-DXd）是一种抗体药物共轭物（ADC），针对各种类型的 HER2 阳性恶性肿瘤。通过其独特的成分，T-DXd 可实现选择性有效载荷递送，诱导细胞死亡并阻止肿瘤进展。临床试验最初研究了 T-DXd 对 HER2 阳性晚期或转移性乳腺癌、胃癌、肺癌和结直肠癌的疗效；然而，DESTINY-PanTumor02 试验的最新结果进一步强调了 T-DXd 的多功能性，促使 T-DXd 获得美国 FDA 批准用于 HER2 阳性（免疫组化 [IHC] 3+）实体瘤。此外，除了 T-DXd 对脑转移的疗效外，T-DXd 对 HER2 低和 HER2 超低的转移性乳腺癌也显示出良好的疗效，这表明有更多的患者可能从中受益。

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Trastuzumab-Deruxtecan: Redefining HER2 as a Tumor Agnostic Biomarker.

Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2-positive malignancies across various tumor types. Through its unique composition, T-DXd achieves selective payload delivery, inducing cell death and halting tumor progression. Clinical trials initially investigated T-DXd's efficacy in HER2-positive advanced or metastatic breast, gastric, lung, and colorectal cancers; however, recent results from the DESTINY-PanTumor02 trial further underscore T-DXd's versatility, prompting T-DXd's US FDA approval for HER2-positive (immunohistochemistry [IHC] 3+) solid tumors. Moreover, in addition to T-DXd's efficacy against brain metastasis, T-DXd is showing promising results in HER2-low and HER2-ultra-low metastatic breast cancer, indicating a broader population of patients who may benefit.

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来源期刊

Targeted Oncology 医学-肿瘤学

CiteScore

8.40

自引率

3.70%

发文量

审稿时长

>12 weeks

期刊介绍： Targeted Oncology addresses physicians and scientists committed to oncology and cancer research by providing a programme of articles on molecularly targeted pharmacotherapy in oncology. The journal includes: Original Research Articles on all aspects of molecularly targeted agents for the treatment of cancer, including immune checkpoint inhibitors and related approaches. Comprehensive narrative Review Articles and shorter Leading Articles discussing relevant clinically established as well as emerging agents and pathways. Current Opinion articles that place interesting areas in perspective. Therapy in Practice articles that provide a guide to the optimum management of a condition and highlight practical, clinically relevant considerations and recommendations. Systematic Reviews that use explicit, systematic methods as outlined by the PRISMA statement. Adis Drug Reviews of the properties and place in therapy of both newer and established targeted drugs in oncology.