Metalloproteins 结构和功能对免疫模式的启示。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Chandrabose Selvaraj, Periyasamy Vijayalakshmi, Asha Monica Alex, Abdulaziz S Alothaim, Rajendran Vijayakumar, Vidhya Rekha Umapathy
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引用次数: 0

摘要

金属蛋白在调节人体免疫系统的不同方面发挥着至关重要的作用。它们在免疫中具有多种功能,包括识别和呈现抗原、帮助免疫细胞的移动和发挥效力,以及促进宿主与病原体之间的相互作用。了解这些蛋白质的工作原理有助于我们开发控制不同疾病免疫反应的新方法。金属蛋白的结构中含有金属离子,这使它们能够发挥这些不同的功能。它们包括各种利用金属离子作为辅助因子进行活动的酶、信号分子和结构蛋白。金属蛋白的例子包括超氧化物歧化酶、过氧化氢酶和金属蛋白酶,它们调节氧化应激、炎症和与免疫激活相关的组织重塑过程。通过研究它们的功能及其功能障碍的影响,研究人员可以开发出改善免疫功能和防治各种疾病的策略。这篇综述探讨了金属蛋白在免疫过程中的各种功能,强调了它们在健康和疾病中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metalloproteins structural and functional insights into immunological patterns.

Metalloproteins play a crucial role in regulating different aspects of the immune system in humans. They have various functions in immunity, including recognizing and presenting antigens, aiding in the movement and effectiveness of immune cells, and facilitating interactions between the host and pathogens. Understanding how these proteins work can help us develop new methods to control the immune response in different diseases. Metalloproteins contain metal ions in their structure, which allows them to perform these diverse functions. They encompass a wide range of enzymes, signaling molecules, and structural proteins that utilize metal ions as cofactors for their activities. Examples of metalloproteins include superoxide dismutase, catalase, and metalloproteases, which regulate oxidative stress, inflammation, and tissue remodelling processes associated with immune activation. By studying their functions and the effects of their dysfunction, researchers can develop strategies to improve immune function and combat various diseases. This review explores the diverse functions of metalloproteins in immune processes, highlighting their significance in both health and disease.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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