关于一名接受三联疫苗接种和利妥昔单抗治疗的系统性红斑狼疮患者 COVID-19 肺炎的病例报告和文献综述。

IF 1.4 4区 医学 Q3 RHEUMATOLOGY
ARP Rheumatology Pub Date : 2024-04-01
Christos Michailides, Themistoklis Paraskevas, Maria Lagadinou, Konstantinos Papantoniou, Michail Kavvousanos, Markos Marangos, Dimitrios Velissaris
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引用次数: 0

摘要

导言因任何原因接受免疫抑制治疗的患者,加上吸烟和肥胖等其他危险因素,很容易感染 SARS-CoV2。本报告旨在描述一例正在接受利妥昔单抗治疗的女性患者,尽管她已接种了完全的疫苗,但仍因严重急性冠状病毒 2(SARS-CoV-2)入侵而出现肺部感染:一名 50 岁的女性患者,既往有狼疮性肾炎病史,在接受利妥昔单抗治疗后被诊断为严重急性冠状病毒 2 型(SARS-CoV-2)引起的肺部感染。八个月后,在最后一次输注利妥昔单抗(RTX)后,她患上了中度冠状病毒病 2019(COVID-19)。在部分康复后,她的呼吸道症状加重,导致再次入院并进行有创吸氧。31 天后,她最终出院回家。每月一次的神经系统评估未发现疾病活动迹象。她后来接受了静脉注射免疫球蛋白,并决定重新开始利妥昔单抗治疗:本病例提出了在接受利妥昔单抗治疗的系统性红斑狼疮患者中存在病毒持续脱落和严重急性呼吸综合征冠状病毒再激活的可能性。我们强调,在 COVID-19 大流行期间,对自身免疫性疾病患者的管理要有精确的考虑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case report and literature review of a triple-vaccinated, rituximab-treated systemic lupus erythematosus patient with COVID-19 pneumonia.

Introduction: Patients being on immunosuppressive treatment of any reason, along with other risk factors such as smoking and obesity, are vulnerable to be infected from SARS-CoV2. Aim of this report is to describe a case of a female patient under Rituximab therapy who experienced episodes of lung infection due to Severe Acute Coronavirus 2 (SARS-CoV-2 ) invasion although fully vaccinated.

Case report: A 50-year-old woman, with a past medical history of lupus nephritis on rituximab was diagnosed with lung infection due to SARS-CoV-2. Eight months later, following her last infusion of Rituximab (RTX), she developed moderate Coronavirus Disease 2019 (COVID-19). After a partial recovery, she exhibited exacerbation of respiratory symptoms leading to readmission and invasive oxygenation. She was eventually discharged home after 31 days. Her monthly neurological evaluation did not reveal evidence of disease activity. She later received intravenous immunoglobulin and a decision was made to restart rituximab.

Conclusions: This case raises the possibility of persistent virus shedding and reactivation of severe acute respiratory syndrome coronavirus in a patient with SLE and Rituximab therapy. We emphasize a precise consideration of management of patients with autoimmune disorders during the COVID-19 pandemic.

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