阿西替尼对美国一组程序性细胞死亡蛋白1耐药粘膜黑色素瘤患者的疗效。

IF 1.5 4区 医学 Q3 DERMATOLOGY
Melanoma Research Pub Date : 2024-10-01 Epub Date: 2024-06-28 DOI:10.1097/CMR.0000000000000988
Sarah E Lochrin, Marina K Cugliari, Randy Yeh, Alexander N Shoushtari
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引用次数: 0

摘要

粘膜黑色素瘤是一种罕见的黑色素瘤亚型,约占所有确诊黑色素瘤的 1%。其特点是表型具有侵袭性,预后差,对已获批准的治疗方法反应率低。我们回顾性分析了2018年至2021年间在美国一家转诊中心接受阿西替尼±抗程序性细胞死亡蛋白1(PD-1)治疗的确诊粘膜黑色素瘤患者的临床特征、治疗方法和结果。放射学反应根据实体瘤反应评估标准(RECIST)v1.1进行评估。本研究共纳入23名患者。其中78%为女性,中位年龄为62岁。粘膜黑色素瘤的起源部位为鼻窦(35%)、泌尿生殖系统(35%)和胃肠道(30%)。65%的患者患有M1c或M1d疾病,0%的患者检测到BRAF V600突变。大多数患者(96%)既往接受过抗PD-1治疗,中位数为2次,78%的患者接受过阿西替尼和PD-1联合治疗,中位治疗时间为3.2个月。总体反应率为13%,疾病控制率为26%。中位无进展生存期为3.2个月,中位总生存期为8.2个月。总体而言,该疗法耐受性良好,39%的患者需要减少剂量,9%的患者需要停止治疗。阿昔替尼联合抗PD-1疗法在亚洲以外地区接受过大量预处理的粘膜黑色素瘤患者中具有适度的临床活性,其中一些患者可长期获益。这些数据支持在全球范围内对这种联合疗法进行临床试验评估,并支持将基于血管内皮生长因子的疗法纳入粘膜黑色素瘤患者的治疗范例中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of axitinib in a US cohort of patients with programmed cell death protein 1-resistant mucosal melanoma.

Mucosal melanoma is a rare melanoma subtype, accounting for about 1% of all diagnosed melanomas. It is characterized by an aggressive phenotype with a poor prognosis and a low response rate to approved treatments. We retrospectively analyzed the clinical features, treatments, and outcomes of patients diagnosed with mucosal melanoma treated with axitinib ± anti-programmed cell death protein 1 (PD-1) therapy at a single US referral center between 2018 and 2021. Radiologic response was assessed according to Response Evaluation Criteria in Solid Tumors (RECIST), v1.1. Twenty-three patients were included in this study. In all, 78% were females with a median age of 62 years. The originating site of mucosal melanoma was the sinonasal (35%), genitourinary (35%), and gastrointestinal (30%) tracts. Sixty-five percent of patients had M1c or M1d disease and 0% had BRAF V600 mutations detected. The majority (96%) had prior treatment inclusive of anti-PD-1, with a median of 2 prior lines, and 78% of patients received a combination of axitinib and PD-1 and the median duration of treatment was 3.2 months. The overall response rate was 13% and the disease control rate was 26%. The median progression-free survival was 3.2 months, and the median overall survival was 8.2 months. Overall, the regimen was well tolerated with 39% of patients requiring dose reduction and 9% requiring treatment cessation. Axitinib with anti-PD-1 therapy has modest clinical activity in heavily pretreated patients with mucosal melanoma outside of Asia, including some with long-term benefits. This data supports the worldwide clinical trials evaluating this combination and the role of incorporating vascular endothelial growth factor-based therapy in the therapeutic paradigm for patients with mucosal melanoma.

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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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