成骨细胞系的承诺、分化、骨形成和稳态的细胞信号和转录调控。

IF 13 1区 生物学 Q1 CELL BIOLOGY
Siyu Zhu, Wei Chen, Alasdair Masson, Yi-Ping Li
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引用次数: 0

摘要

成骨的启动主要发生在间充质干细胞分化成成骨细胞的过程中。这一分化过程在骨形成和稳态中起着至关重要的作用,并受两个复杂过程的调控:细胞信号传导和转录基因表达。各种重要的细胞信号通路,包括 Wnt、BMP、TGF-β、Hedgehog、PTH、FGF、Ephrin、Notch、Hippo 和 Piezo1/2,在促进成骨细胞分化、骨形成和骨稳态中发挥着关键作用。这一分化过程中的关键转录因子包括 Runx2、Cbfβ、Runx1、Osterix、ATF4、SATB2 和 TAZ/YAP。此外,一系列不同的表观遗传因子也在成骨细胞分化、骨形成和转录水平的平衡中发挥着关键作用。这篇综述概述了细胞信号传导途径、激素调控、参与成骨细胞系的承诺和分化的基因转录调控以及骨形成和维持稳态的最新进展和目前的理解。本文还回顾了通过组蛋白和 DNA 修饰等机制对成骨细胞分化的表观遗传调控。此外,我们还总结了成骨细胞生物学在各种现代技术和生物信息学的推动下取得的最新进展。这篇综述将这些见解综合为对成骨细胞分化的全面理解,进一步阐明了成骨细胞系承诺、分化和骨形成的内在机制,并强调了治疗骨病的潜在新疗法应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis.

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis.

The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is regulated by two intricate processes: cell signal transduction and transcriptional gene expression. Various essential cell signaling pathways, including Wnt, BMP, TGF-β, Hedgehog, PTH, FGF, Ephrin, Notch, Hippo, and Piezo1/2, play a critical role in facilitating osteoblast differentiation, bone formation, and bone homeostasis. Key transcriptional factors in this differentiation process include Runx2, Cbfβ, Runx1, Osterix, ATF4, SATB2, and TAZ/YAP. Furthermore, a diverse array of epigenetic factors also plays critical roles in osteoblast differentiation, bone formation, and homeostasis at the transcriptional level. This review provides an overview of the latest developments and current comprehension concerning the pathways of cell signaling, regulation of hormones, and transcriptional regulation of genes involved in the commitment and differentiation of osteoblast lineage, as well as in bone formation and maintenance of homeostasis. The paper also reviews epigenetic regulation of osteoblast differentiation via mechanisms, such as histone and DNA modifications. Additionally, we summarize the latest developments in osteoblast biology spurred by recent advancements in various modern technologies and bioinformatics. By synthesizing these insights into a comprehensive understanding of osteoblast differentiation, this review provides further clarification of the mechanisms underlying osteoblast lineage commitment, differentiation, and bone formation, and highlights potential new therapeutic applications for the treatment of bone diseases.

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来源期刊
Cell Discovery
Cell Discovery Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
24.20
自引率
0.60%
发文量
120
审稿时长
20 weeks
期刊介绍: Cell Discovery is a cutting-edge, open access journal published by Springer Nature in collaboration with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). Our aim is to provide a dynamic and accessible platform for scientists to showcase their exceptional original research. Cell Discovery covers a wide range of topics within the fields of molecular and cell biology. We eagerly publish results of great significance and that are of broad interest to the scientific community. With an international authorship and a focus on basic life sciences, our journal is a valued member of Springer Nature's prestigious Molecular Cell Biology journals. In summary, Cell Discovery offers a fresh approach to scholarly publishing, enabling scientists from around the world to share their exceptional findings in molecular and cell biology.
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