子宫内膜样癌和非子宫内膜样癌高级别子宫内膜癌的错配修复状态。

Triada Doulgeraki, Stylianos Vagios, Evangelia Kavoura, Petros Yiannou, Irini Messini, Afroditi Nonni, Christos Papadimitriou, Athanassios Vlachos, Kitty Pavlakis
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引用次数: 0

摘要

目的:评估一系列高级别子宫内膜癌的错配修复(MMR)状态,并将其与一些临床病理特征和生存率相关联:研究纳入了 101 例高级别子宫内膜癌(包括子宫内膜样癌和非子宫内膜样癌)患者。免疫组化法评估了 MLH1、MSH2、MSH6 和 PMS2 的表达:结果:在我们的队列中,41 名妇女患有子宫内膜样癌,60 名妇女患有非子宫内膜样癌。据统计,子宫内膜样组织型在缺乏 MMR(dMMR)的肿瘤中更为常见(73.3%),而非子宫内膜样癌则在精通 MMR(pMMR)的病例中占 73.8%(p 结论:在我们的这组高级别子宫内膜癌患者中,子宫内膜样组织型在缺乏 MMR(dMMR)的肿瘤中更为常见(73.3%):在我们这组高级别子宫内膜癌中,据统计,子宫内膜样癌中 MMR 缺乏的发生率高于非子宫内膜样癌。此外,只有 dMMR 子宫内膜样 3 级癌与侵袭性特征有关。考虑到每种 MMR 蛋白与不同临床病理特征的独特关系,建议对所有四种蛋白进行评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mismatch repair status in high-grade endometrial carcinomas of endometrioid and non-endometrioid type.

Purpose: To evaluate mismatch repair (MMR) status in a series of high-grade endometrial carcinomas and correlate it with several clinicopathological characteristics and with survival.

Methods: One hundred and one patients with high-grade endometrial carcinoma, both of endometrioid and of non-endometrioid type were included in the study. The expression of MLH1, MSH2, MSH6 and PMS2 was evaluated by immunohistochemistry.

Results: In our cohort, 41 women had an endometrioid and 60 women a non-endometrioid carcinoma. Endometrioid histotype was statistically more frequent in deficient MMR (dMMR) tumors (73.3%), while non-endometrioid carcinomas in proficient (pMMR) cases (73.8%) (p<0.001). When analyzing the group of endometrioid and non-endometrioid carcinomas separately, only dMMR endometrioid cancers were found to be statistically related to deep myometrial invasion, lymph-node metastases and advanced stage (p=0.035, p=0.011 and p=0.028, respectively). Univariate and multivariate analysis revealed no relation between MMR status and progression-free survival (PFS) or overall survival (OS). Adjuvant treatment was not found to influence the course of the disease. When MMR proteins were studied separately, MLH1/PMS2 loss was related to deep myometrial invasion (p=0.019 and p=0.036, respectively) and MSH6 loss to lymph-node metastases (p=0.04).

Conclusions: In our group of high-grade endometrial carcinomas, MMR deficiency was statistically more frequent in endometrioid than in non-endometrioid cancers. Furthermore, only dMMR endometrioid type grade 3 carcinomas were found to be related with features indicative of aggressive behavior. Considering some unique relation of each MMR protein with distinct clinicopathological features, the assessment of all four proteins is proposed.

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