COVID-19 减缓措施期间早产儿的特征。

IF 1.4 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Yizhen Amy Liu, Alexia Matheson, Rochelle Sleaby, Brendan Mulcahy, Kirsten R Palmer, Ryan J Hodges, Ben W Mol, Atul Malhotra, Daniel L Rolnik
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引用次数: 0

摘要

背景:材料与方法:我们进行了一项回顾性队列研究,比较了在墨尔本三家妇产医院分娩并在 2019 年 11 月至 2020 年 2 月期间受孕的早产妇女(采取缓解措施):我们进行了一项回顾性队列研究,将在墨尔本三家妇产医院分娩并在 2019 年 11 月至 2020 年 2 月期间受孕的早产妇女(采取缓解措施的队列)与在 2018 年 11 月至 2019 年 2 月期间分娩并受孕的早产妇女(未采取缓解措施的队列)进行了比较。我们比较了产妇特征、妊娠并发症、产前干预、产中护理和分娩指征:在暴露队列中,252/3129 名妇女早产(8.1%),而在非暴露队列中,298/3154 名妇女早产(9.4%)(几率比(OR)0.84,95% CI 0.70-1.00,P = 0.051)。两个组群的基线特征具有可比性。暴露人群中自发性早产(sPTL)和早产前胎膜破裂(PPROM)的发生率较低(13.1% vs 24.2%,OR 0.47,P = 0.001),而早产前胎膜破裂的发生率较高(48.0% vs 35.6%,OR 1.67,P = 0.003)。在未发生 PPROM 的 sPTL(35.4 周 vs 34.9 周,P = 0.703)和 PPROM(35.6 周 vs 34.9 周,P = 0.184)组群中,采取缓解措施的妊娠期延长无统计学意义。与非暴露队列相比,暴露队列在 PPROM 后的自然分娩率更高(40.1% vs 24.1%,OR 2.09,P 结语):在采取缓解措施期间,早产率下降的原因可能是未发生 PPROM 的自然分娩率下降,而这似乎会导致妊娠晚期发生更多的 PPROM。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characteristics of preterm births during COVID-19 mitigation measures.

Background: During the COVID-19 pandemic, mitigation measures were associated with a reduction in preterm birth rates; while not clearly proven, this observation has sparked significant interest.

Aim: To understand the cause of this reduction by exploring the characteristics of preterm birth cohorts.

Material and methods: We performed a retrospective cohort study where we compared women who delivered preterm in three Melbourne maternity hospitals and conceived between November 2019 and February 2020 (mitigation measures-exposed cohort) to women who delivered preterm and conceived between November 2018 and February 2019 (non-exposed cohort). We compared maternal characteristics, pregnancy complications, antenatal interventions, intrapartum care, and indications for delivery.

Results: In the exposed cohort, 252/3129 women delivered preterm (8.1%), vs 298/3154 (9.4%) in the non-exposed cohort (odds ratio (OR) 0.84, 95% CI 0.70-1.00, P = 0.051). The baseline characteristic of two cohorts were comparable. Rates of spontaneous preterm labour (sPTL) without preterm pre-labour rupture of membranes (PPROM) were lower in the exposed cohort (13.1% vs 24.2%, OR 0.47, P = 0.001) while PPROM occurred more often (48.0% vs 35.6%, OR 1.67, P = 0.003). With a non-statistically significant prolongation of pregnancy in the cohort exposed to mitigation measures for both sPTL without PPROM (35.4 vs 34.9 weeks, P = 0.703) and PPROM (35.6 vs 34.9 weeks, P = 0.184). The rate of spontaneous labour after PPROM was higher in the exposed cohort compared to the non-exposed cohort (40.1% vs 24.1%, OR 2.09, P < 0.001).

Conclusion: The reduction in preterm delivery during mitigation measures may have been driven by a reduction in spontaneous labour without PPROM, which seemed to result in more PPROM later in pregnancy.

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来源期刊
CiteScore
3.40
自引率
11.80%
发文量
165
审稿时长
4-8 weeks
期刊介绍: The Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJOG) is an editorially independent publication owned by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) and the RANZCOG Research foundation. ANZJOG aims to provide a medium for the publication of original contributions to clinical practice and/or research in all fields of obstetrics and gynaecology and related disciplines. Articles are peer reviewed by clinicians or researchers expert in the field of the submitted work. From time to time the journal will also publish printed abstracts from the RANZCOG Annual Scientific Meeting and meetings of relevant special interest groups, where the accepted abstracts have undergone the journals peer review acceptance process.
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