利用两种非光刻沉积技术开发富含纳米间隙的混合金纳米结构,用于灵敏可靠的 SERS 生物传感器。

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Biomedical Engineering Letters Pub Date : 2024-05-29 eCollection Date: 2024-07-01 DOI:10.1007/s13534-024-00381-4
Hyuck Ju Kwon, Yong Jun Cho, Kyeong Min Yuk, Jonghwan Lee, Seung Ho Choi, Kyung Min Byun
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引用次数: 0

摘要

表面增强拉曼光谱(SERS)的实际应用受到热点异质分布的限制,例如信号波动大,导致检测可靠性低。在此,我们通过在均匀的金纳米岛(GNI)图案上设计空间均匀的金纳米粒子(GNPs),开发了一种更灵敏、更可靠的 SERS 平台策略。通过结合电子束蒸发和对流自组装这两种非光刻技术,成功地制造出了所提出的 SERS 基底。这些自下而上的方法实现了简单、经济和大面积的制造。与通过两种独立的纳米制造方法获得的 SERS 基底相比,含有 GNPs 和 GNIs 的样品测量到的拉曼光谱信号强度显著增加,信号波动也明显改善。模拟近场分析表明,在 GNP-GNI 接口内部和间隙处形成了高度放大的等离子体模式。此外,我们还对所建议的 SERS 传感器进行了葡萄糖浓度检测评估,结果表明,与只有 GNI 图案的样品相比,检测灵敏度提高了 10 倍以上,而且空间重现性相当好,达到了 7%。相信我们的建议能为高灵敏度、低成本和可靠的 SERS 生物传感平台提供潜力,为医疗保健设备带来诸多优势:在线版本包含补充材料,可查阅 10.1007/s13534-024-00381-4。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of nanogap-rich hybrid gold nanostructures by use of two non-lithographic deposition techniques for a sensitive and reliable SERS biosensor.

Practical application of surface-enhanced Raman spectroscopy (SERS) has suffered from several limitations by heterogeneous distribution of hot-spots, such as high signal fluctuation and the resulting low reliability in detection. Herein, we develop a strategy of more sensitive and reliable SERS platform through designing spatially homogeneous gold nanoparticles (GNPs) on a uniform gold nanoisland (GNI) pattern. The proposed SERS substrate is successfully fabricated by combining two non-lithographic techniques of electron beam evaporation and convective self-assembly. These bottom-up methods allow a simple, cost-effective, and large-area fabrication. Compared to the SERS substrates obtained from two separate nanofabrication methods, Raman spectra measured by the samples with both GNPs and GNIs present a significant increase in the signal intensity as well as a notable improvement in signal fluctuation. The simulated near-field analyses demonstrate the formation of highly amplified plasmon modes within and at the gaps of the GNP-GNI interfaces. Moreover, the suggested SERS sensor is evaluated to detect the glucose concentration, exhibiting that the detection sensitivity is improved by more than 10 times compared to the sample with only GNI patterns and a fairly good spatial reproducibility of 7% is accomplished. It is believed that our suggestion could provide a potential for highly sensitive, low-cost, and reliable SERS biosensing platforms that include many advantages for healthcare devices.

Supplementary information: The online version contains supplementary material available at 10.1007/s13534-024-00381-4.

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来源期刊
Biomedical Engineering Letters
Biomedical Engineering Letters ENGINEERING, BIOMEDICAL-
CiteScore
6.80
自引率
0.00%
发文量
34
期刊介绍: Biomedical Engineering Letters (BMEL) aims to present the innovative experimental science and technological development in the biomedical field as well as clinical application of new development. The article must contain original biomedical engineering content, defined as development, theoretical analysis, and evaluation/validation of a new technique. BMEL publishes the following types of papers: original articles, review articles, editorials, and letters to the editor. All the papers are reviewed in single-blind fashion.
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