微中风引起的脑组织氧气、葡萄糖和温度的瞬时变化:计算研究。

IF 1.9 4区 医学 Q3 HEMATOLOGY
Marzieh Bagheri, Sajjad Habibzadeh, Mohammad Moeini
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引用次数: 0

摘要

目的:本研究的重点是评估微中风事件中关键生理参数的紊乱情况:本研究的重点是评估微中风事件中关键生理参数的紊乱情况,以评估其严重程度:方法:建立了一个数学模型来模拟血流中断导致的脑组织 pO2、葡萄糖浓度和温度的变化。该模型考虑了基线脑血流量(CBF)、毛细血管密度和血氧/葡萄糖水平的变化以及环境温度的变化:模拟结果表明,完全的血流阻塞仍允许有限的葡萄糖供应,支持非氧化代谢,并可能加剧乳酸积聚和酸中毒。部分阻塞会降低组织 pO2,但对葡萄糖水平的影响极小,葡萄糖水平几乎保持不变,甚至略有上升。由于老化或疾病导致的 CBF、毛细血管密度或血氧降低会增加低阻塞水平的缺氧风险,毛细血管密度通过影响 pO2 和血糖水平对中风严重程度有显著影响。这些情况可能会导致缺氧/低血糖或缺氧/高血糖并发,从而使预后恶化。温度对大脑深部区域的影响微乎其微,但对头骨附近区域的影响则因环境温度不同而有0.2-0.8°C的差异:该模型根据缺氧、低血糖、高血糖和温度变化的估计水平,深入分析了导致严重中风后果的条件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transient Changes in Cerebral Tissue Oxygen, Glucose, and Temperature by Microstrokes: A Computational Study

Objective

This study focuses on evaluating the disruptions in key physiological parameters during microstroke events to assess their severity.

Methods

A mathematical model was developed to simulate the changes in cerebral tissue pO2, glucose concentration, and temperature due to blood flow interruptions. The model considers variations in baseline cerebral blood flow (CBF), capillary density, and blood oxygen/glucose levels, as well as ambient temperature changes.

Results

Simulations indicate that complete blood flow obstruction still allows for limited glucose availability, supporting nonoxidative metabolism and potentially exacerbating lactate buildup and acidosis. Partial obstructions decrease tissue pO2, with minimal impact on glucose level, which can remain almost unchanged or even slightly increase. Reduced CBF, capillary density, or blood oxygen due to aging or disease enhances hypoxia risk at lower obstruction levels, with capillary density having a significant effect on stroke severity by influencing both pO2 and glucose levels. Conditions could lead to co-occurrence of hypoxia/hypoglycemia or hypoxia/hyperglycemia, each worsening outcomes. Temperature effects were minimal in deep brain regions but varied near the skull by 0.2–0.8°C depending on ambient temperature.

Conclusions

The model provides insights into the conditions driving severe stroke outcomes based on estimated levels of hypoxia, hypoglycemia, hyperglycemia, and temperature changes.

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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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