帕金森病患者姿势平衡的趋势变化分析可区分用药状态。

IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Piotr Wodarski, Jacek Jurkojć, Marta Chmura, Elke Warmerdam, Robbin Romijnders, Markus A Hobert, Walter Maetzler, Krzysztof Cygoń, Clint Hansen
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引用次数: 0

摘要

背景:保持静态平衡与日常生活息息相关,也很常见,它取决于正确的节间协调。姿势能力的改变或降低与跌倒风险的增加有关。帕金森病患者(pwPD)的运动症状会影响稳定姿势的维持。本研究的目的是了解姿势摇摆的节段间变化,并应用趋势变化分析来揭示帕金森病患者与健康成人之间不同的运动策略:共纳入 61 名健康参与者、40 名年轻人(YO)、21 名老年人(OP)和 29 名残疾人(13 名在停药期间,PDoff;23 名在服药期间,PDon)。作为短期体能测试的一部分,参与者安静站立 10 秒钟。使用头部、胸骨和腰部的惯性测量单元(IMU)提取姿势参数,并进行趋势变化分析(TCA)以比较组间差异:本研究旨在探索趋势变化分析在使用 IMU 评估姿势稳定性方面的潜在应用,其次是在神经系统疾病(尤其是帕金森病)的背景下采用这种分析方法:对传感器位置进行比较后发现,头部、胸骨和骨盆在几乎所有参数和组群中都存在显著差异。在比较 "帕金森病on "和 "帕金森病off "时,TCA显示出的差异是其他任何参数都无法显示的:结论:虽然所有参数都能区分传感器的位置,但除了 TCA 能区分 "开机 "和 "关机 "之外,其他参数都不能发现组间差异。在未来的研究中,应探索 TCA 在评估疾病进展、治疗反应甚至前驱期 PD 阶段方面的潜力:研究程序已获得基尔大学医学院伦理委员会批准(D438/18)。该研究已在德国临床试验注册中心(DRKS00022998)注册。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Trend change analysis of postural balance in Parkinson's disease discriminates between medication state.

Background: Maintaining static balance is relevant and common in everyday life and it depends on a correct intersegmental coordination. A change or reduction in postural capacity has been linked to increased risk of falls. People with Parkinson's disease (pwPD) experience motor symptoms affecting the maintenance of a stable posture. The aim of the study is to understand the intersegmental changes in postural sway and to apply a trend change analysis to uncover different movement strategies between pwPD and healthy adults.

Methods: In total, 61 healthy participants, 40 young (YO), 21 old participants (OP), and 29 pwPD (13 during medication off, PDoff; 23 during medication on, PDon) were included. Participants stood quietly for 10 s as part of the Short Physical Performance Battery. Inertial measurement units (IMU) at the head, sternum, and lumbar region were used to extract postural parameters and a trend change analysis (TCA) was performed to compare between groups.

Objective: This study aims to explore the potential application of TCA for the assessment of postural stability using IMUs, and secondly, to employ this analysis within the context of neurological diseases, specifically Parkinson's disease.

Results: Comparison of sensors locations revealed significant differences between head, sternum and pelvis for almost all parameters and cohorts. When comparing PDon and PDoff, the TCA revealed differences that were not seen by any other parameter.

Conclusions: While all parameters could differentiate between sensor locations, no group differences could be uncovered except for the TCA that allowed to distinguish between the PD on/off. The potential of the TCA to assess disease progression, response to treatment or even the prodromal PD phase should be explored in future studies.

Trial registration: The research procedure was approved by the ethical committee of the Medical Faculty of Kiel University (D438/18). The study is registered in the German Clinical Trials Register (DRKS00022998).

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来源期刊
Journal of NeuroEngineering and Rehabilitation
Journal of NeuroEngineering and Rehabilitation 工程技术-工程:生物医学
CiteScore
9.60
自引率
3.90%
发文量
122
审稿时长
24 months
期刊介绍: Journal of NeuroEngineering and Rehabilitation considers manuscripts on all aspects of research that result from cross-fertilization of the fields of neuroscience, biomedical engineering, and physical medicine & rehabilitation.
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