来自入侵性流感嗜血杆菌血清型 a 疾病不同发病率地区的儿童鼻咽部的流感嗜血杆菌流行率:加拿大免疫研究网络(CIRN)研究。

IF 1.3 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Marina Ulanova, Raymond Sw Tsang, David M Goldfarb, Marek Smieja, Brenda Huska, Kathy Luinstra, Nicole Le Saux
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引用次数: 0

摘要

近来,a 型流感嗜血杆菌(Hia)已成为北美北极和亚北极地区侵袭性疾病的重要病因,主要影响年幼的土著儿童。在这项研究中,我们探讨了鼻咽部 Hia 和所有流感杆菌的流行率在 Hia 侵袭性疾病高发和低发地区的儿科人群中是否存在差异的问题。通过分子遗传学方法对采集的急性呼吸道感染(ARTI)患儿鼻咽标本进行呼吸道病毒常规诊断检测分析,以确定流感嗜血杆菌的血清型。在侵袭性 Hia 病高发地区努纳武特,60.6% 和 3.0% 的儿童在鼻咽部发现了所有流感嗜血杆菌,尤其是 Hia。在安大略省南部(汉密尔顿地区),Hia侵袭性疾病很少发生,所有流感嗜血杆菌和Hia的检出率分别为38.5%和0.6%。在这两个队列中,非类型流感嗜血杆菌都很普遍(分别为 57.0% 和 37.9%)。考虑到 Hia 是造成努纳武特地区儿童严重侵袭性疾病的一个重要原因,ARTI 儿童中 3% 的 Hia 感染率可能反映了病原体在北部社区的持续传播,这可能会导致侵袭性疾病的爆发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of Haemophilus influenzae in the nasopharynx of children from regions with varying incidence of invasive H. influenzae serotype a disease: Canadian Immunization Research Network (CIRN) study.

Haemophilus influenzae serotype a (Hia) has recently emerged as an important cause of invasive disease in the North American Arctic and Sub-Arctic regions, mainly affecting young Indigenous children. In this study, we addressed the question of whether the prevalence of Hia and all H. influenzae in the nasopharynx differed between paediatric populations from regions with high versus low incidence of invasive Hia disease. Nasopharyngeal specimens from children with acute respiratory tract infections (ARTI) collected for routine diagnostic detection of respiratory viruses were analysed with molecular-genetic methods to identify and serotype H. influenzae. In Nunavut, a region with a high incidence of invasive Hia disease, all H. influenzae and particularly Hia were found in the nasopharynx of 60.6% and 3.0% children. In Southern Ontario (Hamilton region), where Hia invasive disease is rare, the frequencies of all H. influenzae and Hia detection were 38.5% and 0.6%, respectively. In both cohorts, non-typeable H. influenzae was prevalent (57.0% and 37.9%, respectively). Considering that Hia is an important cause of severe invasive disease in Nunavut children, 3% prevalence of Hia among children with ARTI can reflect continuing circulation of the pathogen in the Northern communities that may result in invasive disease outbreaks.

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来源期刊
International Journal of Circumpolar Health
International Journal of Circumpolar Health 医学-公共卫生、环境卫生与职业卫生
CiteScore
2.10
自引率
15.40%
发文量
51
审稿时长
6-12 weeks
期刊介绍: The International Journal of Circumpolar Health is published by Taylor & Francis on behalf of the Circumpolar Health Research Network [CircHNet]. The journal follows the tradition initiated by its predecessor, Arctic Medical Research. The journal specializes in circumpolar health. It provides a forum for many disciplines, including the biomedical sciences, social sciences, and humanities as they relate to human health in high latitude environments. The journal has a particular interest in the health of indigenous peoples. It is a vehicle for dissemination and exchange of knowledge among researchers, policy makers, practitioners, and those they serve. International Journal of Circumpolar Health welcomes Original Research Articles, Review Articles, Short Communications, Book Reviews, Dissertation Summaries, History and Biography, Clinical Case Reports, Public Health Practice, Conference and Workshop Reports, and Letters to the Editor.
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