脊髓损伤中的 microRNA 研究进展。

Q3 Medicine

生理学报 Pub Date : 2024-06-25

Dong-Min Wei, Rui Fang, Zhi-Zhong Deng, Xin-Yue Bai, Jing-Hui Zhu, Tian-Yu Zhai, Can Zhang, Jian-Zhong Gao, Dan Su, Yan-Ling Yang, Lin Zhao

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引用次数: 0

摘要

脊髓损伤（SCI）是一种严重的中枢神经系统疾病，致残率和死亡率高，病理生理机制复杂。miRNA参与调控脊髓损伤后的炎症反应、氧化应激、轴突再生和细胞凋亡，并与长非编码RNA（lnRNA）和环状RNA（circRNA）相互作用，调控脊髓损伤的病理生理过程。本文总结了 miRNA 在 SCI 后的表达变化，综述了 miRNA 在 SCI 中的靶向机制和 miRNA 靶向药物的研究现状，为 SCI 的基础和临床研究提供新靶点和新视野。

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Research progress of microRNA in spinal cord injury.

Spinal cord injury (SCI) is a serious central nervous system disease with high disability and mortality rates and complex pathophysiologic mechanisms. MicroRNA (miRNA), as a kind of non-coding RNA, plays an important role in SCI. miRNA is involved in the regulation of inflammatory response, oxidative stress, axonal regeneration, and apoptosis after SCI, and interacts with long non-coding RNA (lncRNA) and circular RNA (circRNA) to regulate the pathophysiological process of SCI. This paper summarizes the changes in miRNA expression after SCI, and reviews the targeting mechanism of miRNA in SCI and the current research status of miRNA-targeted drugs to provide new targets and new horizons for basic and clinical research on SCI.

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.