为计算机辅助细胞学诊断去除背景杂质。

IF 2.3 3区 医学 Q3 ENGINEERING, BIOMEDICAL
Keita Takeda, Tomoya Sakai, Eiji Mitate
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引用次数: 0

摘要

为了解决显微载玻片变质导致的计算机辅助细胞学中的背景偏差问题,本文提出了一种无需细胞注释即可进行细胞分割和背景去除的深度学习方法。利用液基细胞学(LBC)图像中背景的冗余性和细胞的稀疏性,训练了一个基于 U-Net 的模型,以无监督的方式将细胞从背景中分离出来。实验结果表明,基于 U-Net 的模型在一小部分细胞学图像上经过训练后,可以排除背景特征,准确分割细胞。这种能力有利于在口腔 LBC 中对感兴趣的细胞进行检测和分类。切片劣化会严重影响基于深度学习的细胞分类。我们提出的方法能在不影响细胞标注的情况下有效去除背景特征,从而通过对显微载玻片图像的深度学习实现准确的细胞学诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Background removal for debiasing computer-aided cytological diagnosis.

Background removal for debiasing computer-aided cytological diagnosis.

To address the background-bias problem in computer-aided cytology caused by microscopic slide deterioration, this article proposes a deep learning approach for cell segmentation and background removal without requiring cell annotation. A U-Net-based model was trained to separate cells from the background in an unsupervised manner by leveraging the redundancy of the background and the sparsity of cells in liquid-based cytology (LBC) images. The experimental results demonstrate that the U-Net-based model trained on a small set of cytology images can exclude background features and accurately segment cells. This capability is beneficial for debiasing in the detection and classification of the cells of interest in oral LBC. Slide deterioration can significantly affect deep learning-based cell classification. Our proposed method effectively removes background features at no cost of cell annotation, thereby enabling accurate cytological diagnosis through the deep learning of microscopic slide images.

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来源期刊
International Journal of Computer Assisted Radiology and Surgery
International Journal of Computer Assisted Radiology and Surgery ENGINEERING, BIOMEDICAL-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
5.90
自引率
6.70%
发文量
243
审稿时长
6-12 weeks
期刊介绍: The International Journal for Computer Assisted Radiology and Surgery (IJCARS) is a peer-reviewed journal that provides a platform for closing the gap between medical and technical disciplines, and encourages interdisciplinary research and development activities in an international environment.
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