调整突触可塑性：解密 WWC1 在记忆中的作用开辟了新的治疗前景。

IF 6.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Science Signaling Pub Date : 2024-06-25 DOI:10.1126/scisignal.adp5354

Andreas Papassotiropoulos, Dominique J.-F. de Quervain

引用次数: 0

摘要

WWC1 是进化保守的 Hippo 信号网络中的一个支架蛋白，在遗传学上与人类记忆和突触可塑性有关。在《科学信号》杂志的档案中，Stepan 等人展示了通过药物抑制希波通路激酶来调节 WWC1 以增强认知能力的转化潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons

WWC1 is a scaffolding protein in the evolutionarily conserved Hippo signaling network and is genetically linked to human memory and synaptic plasticity. In the archives of Science Signaling, Stepan et al. demonstrate the translational potential of modulating WWC1 through pharmacological inhibition of Hippo-pathway kinases to enhance cognition.

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来源期刊

Science Signaling BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

9.50

自引率

0.00%

发文量

148

审稿时长

3-8 weeks

期刊介绍： "Science Signaling" is a reputable, peer-reviewed journal dedicated to the exploration of cell communication mechanisms, offering a comprehensive view of the intricate processes that govern cellular regulation. This journal, published weekly online by the American Association for the Advancement of Science (AAAS), is a go-to resource for the latest research in cell signaling and its various facets. The journal's scope encompasses a broad range of topics, including the study of signaling networks, synthetic biology, systems biology, and the application of these findings in drug discovery. It also delves into the computational and modeling aspects of regulatory pathways, providing insights into how cells communicate and respond to their environment. In addition to publishing full-length articles that report on groundbreaking research, "Science Signaling" also features reviews that synthesize current knowledge in the field, focus articles that highlight specific areas of interest, and editor-written highlights that draw attention to particularly significant studies. This mix of content ensures that the journal serves as a valuable resource for both researchers and professionals looking to stay abreast of the latest advancements in cell communication science.