聚合物微胶囊纳米凝胶作为乳腺癌治疗中的新兴给药系统:前景与挑战

IF 3 4区 医学 Q2 PHARMACOLOGY & PHARMACY
M Yazdan, S M Naghib, M R Mozafari
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引用次数: 0

摘要

乳腺癌是一个普遍存在的全球性健康问题,对女性人口的影响尤为严重。在过去几年中,纳米技术因其在创建药物输送系统方面的潜在用途而备受关注。这些设备的主要目的是加强靶向药物的输送,优化接受药物的特定细胞,解决恶性细胞的抗药性问题,并引入预防和控制疾病的新策略。本研究旨在研究各种载体纳米粒子在乳腺癌治疗干预中使用的方法。主要目的是研究新型给药技术的潜在应用,以实现及时有效的诊断和治疗。目前的癌症研究主要研究化疗药物的各种给药方法。这些方法包括开发水凝胶、胶束、外泌体和类似化合物。本研究旨在分析这些系统的属性、复杂性、显著进步以及在临床环境中的实际应用。尽管这些方法的疗效已得到证实,但在创新治疗方法的开发进展与临床广泛应用之间仍存在明显差距。要提高基于纳米技术的给药系统在乳腺癌治疗中的有效性,关键是要在这两个变量之间建立稳固的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polymeric Micelle-Based Nanogels as Emerging Drug Delivery Systems in Breast Cancer Treatment: Promises and Challenges.

Breast cancer is a pervasive global health issue that disproportionately impacts the female population. Over the past few years, there has been considerable interest in nanotechnology due to its potential utility in creating drug-delivery systems designed to combat this illness. The primary aim of these devices is to enhance the delivery of targeted medications, optimise the specific cells that receive the drugs, tackle treatment resistance in malignant cells, and introduce novel strategies for preventing and controlling diseases. This research aims to examine the methodologies utilised by various carrier nanoparticles in the context of therapeutic interventions for breast cancer. The main objective is to investigate the potential application of novel delivery technologies to attain timely and efficient diagnosis and treatment. Current cancer research predominantly examines diverse drug delivery methodologies for chemotherapeutic agents. These methodologies encompass the development of hydrogels, micelles, exosomes, and similar compounds. This research aims to analyse the attributes, intricacies, notable advancements, and practical applications of the system in clinical settings. Despite the demonstrated efficacy of these methodologies, an apparent discrepancy can be observed between the progress made in developing innovative therapeutic approaches and their widespread implementation in clinical settings. It is critical to establish a robust correlation between these two variables to enhance the effectiveness of medication delivery systems based on nanotechnology in the context of breast cancer treatment.

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来源期刊
Current drug targets
Current drug targets 医学-药学
CiteScore
6.20
自引率
0.00%
发文量
127
审稿时长
3-8 weeks
期刊介绍: Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.
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