单个中心通过手术和/或射频消融治疗肿瘤诱发骨软化症的长期随访数据

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Calcified Tissue International Pub Date : 2024-09-01 Epub Date: 2024-06-26 DOI:10.1007/s00223-024-01249-6
Saba Samad Memon, Mohd Asif Patel, Anurag Lila, Swati Jadhav, Vijaya Sarathi, Manjiri Karlekar, Rohit Barnabas, Virendra Patil, Suyash Kulkarni, Krantikumar Rathod, Nalini Shah, Tushar Bandgar
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引用次数: 0

摘要

有关射频消融(RFA)治疗肿瘤诱发骨软化症(TIO)的数据仅限于病例报告(约 11 例患者),长期随访数据更是少之又少。我们介绍了印度一家三级医疗中心治疗 TIO 的经验。我们对局部 TIO 患者进行了回顾性研究,并检索了临床、生化、治疗和随访细节。在未补充磷酸盐的情况下,血清磷恢复正常被定义为病情缓解。在 33 名患者(23 名男性)中,有 24 名患者接受了手术作为一线治疗,在中位 5(4-9)年的随访中,分别观察到了 12、3 和 9 名患者的早期缓解、延迟缓解(血磷正常化时间大于 1 个月)和持续缓解。手术后病情缓解的患者与病情持续存在的患者在性别、年龄、肿瘤大小、肿瘤位置和 FGF23 水平方面没有统计学差异。二线/三线治疗包括常规药物治疗和/或再次手术(3例)、放射治疗(3例)、肽受体放射性核素治疗(1例)和射频消融治疗(1例)。两名患者在手术后出现一过性乏力恶化(数周)。10 名患者接受了射频消融治疗(一线治疗 n = 9);在最近 5(4-10)年的随访中,7 名患者病情得到缓解。三名顽固性疾病患者中有两名肿瘤较大(分别为 5.6 厘米和 3.6 厘米)。除了一名患者出现局部溃疡外,没有出现与射频消融术相关的并发症。虽然两组中都有少数患者出现顽固性疾病,但无论是 RFA 还是手术治疗,都没有出现复发。射频消融术与手术相似,都能提供持久的疗效,但顽固性疾病需要多种方式的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Long-Term Follow-Up Data of Tumor-Induced Osteomalacia Managed with Surgery and/or Radiofrequency Ablation from a Single Center.

Long-Term Follow-Up Data of Tumor-Induced Osteomalacia Managed with Surgery and/or Radiofrequency Ablation from a Single Center.

Data on radiofrequency ablation (RFA) in tumor-induced osteomalacia (TIO) are restricted to case reports (~ 11 patients) and long-term follow-up data are further scarce. We describe our experience on managing TIO from a tertiary care center in India. Retrospective study of patients with localized TIO was performed and clinical, biochemical, treatment and follow-up details were retrieved. Normalization of serum phosphorus in absence of phosphate supplementation was defined as remission. Of 33 patients (23 males), 24 patients underwent surgery as first-line treatment, and early remission, delayed remission (> 1 month for phosphorus normalization) and persistence were observed 12, 3, and 9 patients at a median follow-up of 5 (4-9) years. The gender, age, tumor size, location of tumors and FGF23 levels were not statistically different in patients who were in remission after surgery versus those with persistent disease. Second/third line treatment included conventional medical treatment and/or repeat surgery (n = 3), radiotherapy (n = 3), peptide receptor radionuclide therapy (n = 1), RFA (n = 1). Two patients had transient worsening (weeks) of weakness post-surgery. 10 patients underwent RFA (first-line n = 9); at the last follow-up 5 (4-10) years, 7 are in remission. Two of three persistent disease patients had large tumors (5.6 and 3.6 cm). There were no RFA-related complications except local ulcer in one. Although persistent disease was present in a few patients in both arms, there was no recurrence in either RFA or surgical cohort. RFA provide durable response similar to surgery, persistence requires multi-modality treatment.

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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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