胡椒碱的药代动力学药物相互作用:临床前和临床研究综述》。

IF 2.1 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Imtiyaz Ahmed Najar, Sagar Pamu, Anushka Paul, Poonam Arora, Gaganjit Kaur, Manish Kumar
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引用次数: 0

摘要

胡椒碱(酰胺类生物碱)提取自胡椒,在全球范围内被用于各种传统和传统医学体系。据观察,同时服用胡椒碱会对几种高效药物的吸收、膜转运和药物代谢产生微妙的影响。药物相互作用的发生可能会对药代动力学参数产生显著影响,导致有利或不利的药理作用。本研究对胡椒碱的药代动力学药物相互作用进行了全面评估,共收录了 34 篇学术文章(专门针对药代动力学相互作用),包括 62 项研究(56 项临床前研究和 6 项临床研究)。在本研究中,我们认为胡椒碱能够提高多种药物的生物利用度和天然来源的生物活性分子,使其成为一种有效的生物强化剂。通过提高生物利用度,胡椒碱可以减少所需剂量,降低药物成本,最大限度地减少耐药性的发生,并减轻与环丙沙星、氨苄西林、甲硝唑卡马西平、姜黄素和土霉素等多种药物相关的剂量依赖性副作用。然而,少数已发表的研究表明,异烟肼、葛根素、地尔硫卓、去乙酰地尔硫卓和麦格诺尔与胡椒碱或胡椒/曲卡图(主要含胡椒碱)联合口服后,生物利用度会降低。其他几项重要研究表明,与胡椒碱一起使用时,药代动力学特征没有明显变化。含有胡椒碱的药物使其药代动力学特性发生了重大变化,最终使生物利用度较低的药物获得了有利的结果。此外,这些改变还减少了副作用,延长了特定药物的半衰期(T1/2)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
WITHDRAWN: Pharmacokinetic Drug Interactions of Piperine: A Review of Pre-clinical and Clinical Studies

The article has been withdrawn at the request of the author and the editor of the journal Current Drug Metabolism.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham editorial policy on article withdrawal can be found at https://benthamscience.com/editorial-policiesmain.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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来源期刊
Current drug metabolism
Current drug metabolism 医学-生化与分子生物学
CiteScore
4.30
自引率
4.30%
发文量
81
审稿时长
4-8 weeks
期刊介绍: Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism. More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.
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