下截断比例危险率模型在三个人群中产生的广义阶次统计及其在早期疾病阶段敏感性中的应用。

IF 1.2 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Hossein Nadeb, Hamzeh Torabi, Yichuan Zhao
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引用次数: 0

摘要

本文基于三个独立的广义阶次统计样本,对基线分布相同的低截断比例危险率模型的参数进行推断,并给出了一些结果。然后,特别是通过考虑未患病人群、早期患病人群和完全患病人群的诊断测试结果,我们对早期患病阶段参数的敏感性进行了推断。针对不同的先验分布结构,我们得到了最大似然估计器、广义枢轴估计器和一些贝叶斯估计器。此外,还给出了百分位数引导置信区间、广义枢轴置信区间和一些贝叶斯可信区间。蒙特卡罗模拟研究用于评估所获得的点估计器和置信/可信区间以及两个竞争对手的性能。我们使用两个真实数据集来说明所提出的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The generalized order statistics arising from three populations with the lower truncated proportional hazard rate models and its application to the sensitivity to the early disease stage.

In this paper, we present some results to make inference about the parameters of lower truncated proportional hazard rate models with the same baseline distributions based on three independent generalized order statistics samples. Then, especially by considering the results of the diagnostic tests for the non-diseased, early-diseased stage and fully diseased populations, we make inference about sensitivity to the early disease stage parameter. The maximum likelihood estimator, a generalized pivotal estimator and some Bayes estimators are obtained for different structures of prior distributions. The percentile bootstrap confidence interval, a generalized pivotal confidence interval and some Bayesian credible intervals are also presented. A Monte Carlo simulation study is used to evaluate the performances of the obtained point estimators and confidence/credible intervals and two competitors. We use two real datasets to illustrate the proposed methods.

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来源期刊
Journal of Biopharmaceutical Statistics
Journal of Biopharmaceutical Statistics 医学-统计学与概率论
CiteScore
2.50
自引率
18.20%
发文量
71
审稿时长
6-12 weeks
期刊介绍: The Journal of Biopharmaceutical Statistics, a rapid publication journal, discusses quality applications of statistics in biopharmaceutical research and development. Now publishing six times per year, it includes expositions of statistical methodology with immediate applicability to biopharmaceutical research in the form of full-length and short manuscripts, review articles, selected/invited conference papers, short articles, and letters to the editor. Addressing timely and provocative topics important to the biostatistical profession, the journal covers: Drug, device, and biological research and development; Drug screening and drug design; Assessment of pharmacological activity; Pharmaceutical formulation and scale-up; Preclinical safety assessment; Bioavailability, bioequivalence, and pharmacokinetics; Phase, I, II, and III clinical development including complex innovative designs; Premarket approval assessment of clinical safety; Postmarketing surveillance; Big data and artificial intelligence and applications.
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