微波消融术与射频消融术在肝细胞癌中的疗效比较:随机对照试验的系统回顾和元分析。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Imelda Rey, Darmadi Darmadi
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引用次数: 0

摘要

简介肝细胞癌(HCC)是全球癌症相关死亡的主要原因。热消融技术,尤其是射频消融(RFA)和微波消融(MWA),已成为治疗 HCC 的关键方法。本系统综述和荟萃分析旨在对这些方法进行比较,突出它们在治疗 HCC 方面的疗效、优势和局限性。方法:我们在主要数据库(PubMed、MEDLINE、Springer、ProQuest、EBSCOhost、Cochrane 和 EMBASE)中进行了全面的文献检索,以使用 RFA 和 MWA 治疗肝细胞癌的研究为目标。使用随机效应模型对异质性分析和汇总结果进行了评估,以比较两种热消融方法。结果:共纳入 9 项研究,包括 368 名接受 RFA 的患者和 387 名接受 MWA 的患者。研究结果显示,在消融量、完全消融率、局部肿瘤进展、生存率、主要并发症和不良事件的汇总分析中,两者无明显差异。亚组分析显示,非洲裔人群接受 RFA 的局部肿瘤进展风险明显更高。结论:各项研究的结果在统计学上没有明显差异。MWA 有可能在并发症和不良反应风险相当的情况下延长治疗反应时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Efficacy of Microwave versus Radiofrequency Ablation in Hepatocellular Carcinoma: Systematic Review and Meta-Analysis of Randomized-Controlled Trials.

Introduction: Hepatocellular carcinoma (HCC) is a leading global cause of cancer-related deaths. Thermal ablation techniques, especially radiofrequency ablation (RFA) and microwave ablation (MWA), have become pivotal treatments for HCC. This systematic review and meta-analysis aim to compare these modalities, highlighting their efficacy, strengths, and limitations in treating HCC. Methods: A comprehensive literature search was conducted across major databases (PubMed, MEDLINE, Springer, ProQuest, EBSCOhost, Cochrane, and EMBASE) targeting studies on hepatocellular carcinoma with RFA and MWA. Heterogeneity analyses and pooled outcomes using random-effect models with were evaluated to compare both thermal ablation methods. Results: Nine studies, which consists of 368 patients underwent RFA and 387 patients underwent MWA, were included in review. The findings showed no significant differences in pooled analysis of volume of ablation, complete ablation rate, local tumor progression, survival rates, major complications, and adverse events. Subgroup analysis showed significantly higher risk of local tumor progression in RFA in African populations. Conclusion: No statistically significant difference was seen between outcomes across studies. MWA may offer a potential for longer therapeutic response with comparable risk of complications and adverse outcomes.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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