椎间盘内臭氧注射治疗腰椎间盘突出症疼痛的有效性：系统回顾和荟萃分析。

IF 1.4 4区医学 Q3 ORTHOPEDICS

Journal of Back and Musculoskeletal Rehabilitation Pub Date : 2024-01-01 DOI:10.3233/BMR-240024

Min Cheol Chang, Yoo Jin Choo, Isabelle Denis, Christopher Mares, Carl Majdalani, Seoyon Yang

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引用次数: 0

摘要

背景：腰椎间盘突出症（HLDs）引起的腰痛和坐骨神经痛是疼痛门诊常见的主诉症状。在各种治疗方法中，椎间盘内臭氧注射已成为腰椎间盘突出症的有效替代疗法或额外治疗方案：本荟萃分析旨在研究椎间盘内臭氧注射治疗 HLDs 的有效性：我们在 PubMed、Embase、Cochrane Library 和 Scopus 数据库中检索了截至 2024 年 1 月 25 日发表的相关研究。我们纳入了调查椎间盘内臭氧注射对 HLDs 患者疗效的研究。我们使用 Cochrane 协作工具对各项研究的方法学质量进行了评估：在治疗后的⩾6个月，椎间盘内臭氧注射对HLDs患者的治疗效果高于类固醇注射（治疗成功率，6个月：几率比=3.95，95%置信区间[CI][2.44, 6.39]，P< 0.01）或传统药物（视觉模拟量表[VAS]的变化，6个月：标准化平均差[SMD]=1.65，95% CI [1.08, 2.22]，P< 0.01；12个月：SMD=1.52，95% CI [1.08, 2.22]，P< 0.01）：SMD=1.52，95% CI [0.96，2.08]，P< 0.01），但与显微椎间盘切除术的疗效相似（VAS 的变化，18 个月：SMD=-0.05，95% CI [-0.67，0.57]，P= 0.87）。治疗后<6个月时，椎间盘内臭氧注射后VAS评分的降低幅度高于类固醇注射后（1个月后VAS的变化：SMD = 2.53，95% CI [1.84，3.21]，P< 0.01）：结论：椎间盘内臭氧注射可能是治疗 HLDs 患者的有效手段。与类固醇注射和口服药物等其他传统治疗方法相比，椎间盘内臭氧注射具有良好的长期（⩾ 6个月）疗效。

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Effectiveness of intradiscal ozone injections for treating pain following herniated lumbar disc: A systematic review and meta-analysis.

Background: Low back pain and sciatica caused by herniated lumbar discs (HLDs) are common complaints among patients visiting pain clinics. Among the various therapeutic methods, intradiscal ozone injections have emerged as an effective alternative or additional treatment option for HLDs.

Objective: This meta-analysis aimed to investigate the effectiveness of intradiscal ozone injections in the treatment of HLDs.

Methods: We searched the PubMed, Embase, Cochrane Library, and Scopus databases for relevant studies published until January 25, 2024. We included studies that investigated the efficacy of intradiscal ozone injections in patients with HLDs. We evaluated the methodological quality of individual studies using the Cochrane Collaboration tool.

Results: At ⩾ 6 months after treatment, the therapeutic effect of intradiscal ozone injections in patients with HLDs was greater than that of steroid injections (treatment success rate, 6 months: odds ratio = 3.95, 95% confidence interval [CI] [2.44, 6.39], P< 0.01) or conventional medications (changes in the Visual Analog Scale [VAS], 6 months: standardized mean difference [SMD] = 1.65, 95% CI [1.08, 2.22], P< 0.01; 12 months: SMD = 1.52, 95% CI [0.96, 2.08], P< 0.01) but similar to that of microdiscectomy (changes in VAS, 18 months: SMD =-0.05, 95% CI [-0.67, 0.57], P= 0.87). At < 6 months after treatment, the reduction in the VAS score after intradiscal ozone injections was higher than that after steroid injections (changes in VAS, 1 month: SMD = 2.53, 95% CI [1.84, 3.21], P< 0.01).

Conclusion: Intradiscal ozone injections may be a useful therapeutic tool in patients with HLDs. Compared with other conventional treatment methods such as steroid injections and oral medications, intradiscal ozone injection has great long-term (⩾ 6 months) effectiveness.

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来源期刊

Journal of Back and Musculoskeletal Rehabilitation 医学-康复医学

CiteScore

2.70

自引率

0.00%

发文量

194

审稿时长

6 months

期刊介绍： The Journal of Back and Musculoskeletal Rehabilitation is a journal whose main focus is to present relevant information about the interdisciplinary approach to musculoskeletal rehabilitation for clinicians who treat patients with back and musculoskeletal pain complaints. It will provide readers with both 1) a general fund of knowledge on the assessment and management of specific problems and 2) new information considered to be state-of-the-art in the field. The intended audience is multidisciplinary as well as multi-specialty. In each issue clinicians can find information which they can use in their patient setting the very next day.