人参通过C/EBP同源蛋白促进人类口腔癌的自噬和凋亡

IF 4.5 2区 医学 Q1 ONCOLOGY
Cancer Science Pub Date : 2024-06-18 DOI:10.1111/cas.16248
Hyun-Ji Kim, Ji-Ae Shin, Yeong-Geun Lee, Bohwan Jin, Won Woo Lee, Yosub Lee, Su-Jung Choi, Jung-Min Han, Min-Hye Ahn, Ji-Hoon Kim, Dong-Guk Park, Seong-Doo Hong, Se-Chan Kang, Sung-Dae Cho
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引用次数: 0

摘要

俗称生姜的姜科植物 Zingiber officinale(Z. officinale)的根茎因其抗肿瘤作用而被认为是一种潜在的候选药物。然而,人们对生姜对人类口腔癌的化疗作用仍知之甚少。在这项研究中,我们考察了生姜根茎乙醇提取物(ZOE)对口腔癌的影响,并确定了其药理活性成分。ZOE 通过同时诱导自噬和细胞凋亡来发挥其对口腔癌的抑制作用。从机理上讲,ZOE 在口腔癌中诱导的自噬和凋亡归因于活性氧(ROS)介导的内质网应激反应。此外,我们还发现了 ZOE 的两种活性成分--1-脱氢-6-姜酮和 8-舒高醇,它们足以通过增强 CHOP 的表达来刺激自噬的启动和凋亡的诱导。这些结果表明,ZOE 及其两种活性成分可诱导 ROS 生成、上调 CHOP、启动自噬和凋亡,是一种很有前景的治疗人类口腔癌的药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Zingiber officinale promotes autophagy and apoptosis in human oral cancer through the C/EBP homologous protein

Zingiber officinale promotes autophagy and apoptosis in human oral cancer through the C/EBP homologous protein

Zingiber officinale promotes autophagy and apoptosis in human oral cancer through the C/EBP homologous protein

The rhizome of Zingiber officinale (Z. officinale), commonly known as ginger, has been characterized as a potential drug candidate due to its antitumor effects. However, the chemotherapeutic effect of ginger on human oral cancer remains poorly understood. In this study, we examined the effects of an ethanol extract of Z. officinale rhizomes (ZOE) on oral cancer and identified the components responsible for its pharmacological activity. ZOE exerts its inhibitory activity in oral cancer by inducing both autophagy and apoptosis simultaneously. Mechanistically, ZOE-induced autophagy and apoptosis in oral cancer are attributed to the reactive oxygen species (ROS)-mediated endoplasmic reticulum stress response. Additionally, we identified two active components of ZOE, 1-dehydro-6-gingerdione and 8-shogaol, which were sufficient to stimulate autophagy initiation and apoptosis induction by enhancing CHOP expression. These results suggest that ZOE and its two active components induce ROS generation, upregulate CHOP, initiate autophagy and apoptosis, and hold promising therapeutics against human oral cancer.

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来源期刊
Cancer Science
Cancer Science 医学-肿瘤学
自引率
3.50%
发文量
406
审稿时长
2 months
期刊介绍: Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.
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