Hicham Cheikh Hassan, David J Tunnicliffe, Lyn Loyd, Adam Mullan, Ieuan Wickham, Brydee Cashmore, Matthew Jose, Andrew J Mallett
{"title":"肾结石引起的肾衰竭：ANZDATA 登记研究","authors":"Hicham Cheikh Hassan, David J Tunnicliffe, Lyn Loyd, Adam Mullan, Ieuan Wickham, Brydee Cashmore, Matthew Jose, Andrew J Mallett","doi":"10.1093/ndt/gfae137","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Kidney stones are common, with an increasing trend over time, and have been well studied in the general population. However, the incidence and outcomes of kidney stones leading to kidney failure (KF) and the receipt of kidney replacement therapy (KRT) are poorly examined. We examined the incidence of KF due to kidney stones and compared outcomes with KRT patients due to other causes.</p><p><strong>Methods: </strong>We studied adult patients who started KRT (January 1981-December 2020) and are included in the Australia and New Zealand Dialysis and Transplant (ANZDATA) registry. Exposure was KRT patients due to kidney stones, comparing them with patients with other causes. We examined incidence, prevalence, patient survival (KRT and transplant) and graft survival (transplant). Cox regression models were fitted to compare patient survival between the kidney stones and non-kidney stones groups, overall KRT, dialysis and patient and graft survival after kidney transplant.</p><p><strong>Results: </strong>A total of 834 (1.1%) patients commenced KRT due to kidney stones. The incidence was 1.17 per million population per year and remained stable during the study period (annual change -0.3% [95% confidence interval (CI) -1.5-0.9]. Survival was higher in kidney stone patients receiving dialysis compared with the non-kidney stone group [hazard ratio (HR) 0.89 (95% CI 0.82-0.96)], with similar estimates in a matched cohort. In kidney transplant patients, time to transplant was longer for patients with kidney stones compared with non-kidney stone patients (2.5 versus 1.7 years; P = .001). There was no difference in mortality [HR 1.02 (95% CI 0.82-1.28)] or graft loss [HR 1.07 (95% CI 0.79-1.45)] between the kidney stones and non-kidney stones patients in the kidney transplant group.</p><p><strong>Conclusion: </strong>The incidence of KF due to kidney stones was unchanged over the study period. Survival of patients with kidney stones who require KRT was better compared with patients with other causes. For the kidney transplant group, survival and risk of graft failure were similar.</p>","PeriodicalId":19078,"journal":{"name":"Nephrology Dialysis Transplantation","volume":" ","pages":"320-328"},"PeriodicalIF":4.8000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792657/pdf/","citationCount":"0","resultStr":"{\"title\":\"Kidney failure from kidney stones: an ANZDATA study.\",\"authors\":\"Hicham Cheikh Hassan, David J Tunnicliffe, Lyn Loyd, Adam Mullan, Ieuan Wickham, Brydee Cashmore, Matthew Jose, Andrew J Mallett\",\"doi\":\"10.1093/ndt/gfae137\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Kidney stones are common, with an increasing trend over time, and have been well studied in the general population. However, the incidence and outcomes of kidney stones leading to kidney failure (KF) and the receipt of kidney replacement therapy (KRT) are poorly examined. We examined the incidence of KF due to kidney stones and compared outcomes with KRT patients due to other causes.</p><p><strong>Methods: </strong>We studied adult patients who started KRT (January 1981-December 2020) and are included in the Australia and New Zealand Dialysis and Transplant (ANZDATA) registry. Exposure was KRT patients due to kidney stones, comparing them with patients with other causes. We examined incidence, prevalence, patient survival (KRT and transplant) and graft survival (transplant). Cox regression models were fitted to compare patient survival between the kidney stones and non-kidney stones groups, overall KRT, dialysis and patient and graft survival after kidney transplant.</p><p><strong>Results: </strong>A total of 834 (1.1%) patients commenced KRT due to kidney stones. The incidence was 1.17 per million population per year and remained stable during the study period (annual change -0.3% [95% confidence interval (CI) -1.5-0.9]. Survival was higher in kidney stone patients receiving dialysis compared with the non-kidney stone group [hazard ratio (HR) 0.89 (95% CI 0.82-0.96)], with similar estimates in a matched cohort. In kidney transplant patients, time to transplant was longer for patients with kidney stones compared with non-kidney stone patients (2.5 versus 1.7 years; P = .001). There was no difference in mortality [HR 1.02 (95% CI 0.82-1.28)] or graft loss [HR 1.07 (95% CI 0.79-1.45)] between the kidney stones and non-kidney stones patients in the kidney transplant group.</p><p><strong>Conclusion: </strong>The incidence of KF due to kidney stones was unchanged over the study period. Survival of patients with kidney stones who require KRT was better compared with patients with other causes. For the kidney transplant group, survival and risk of graft failure were similar.</p>\",\"PeriodicalId\":19078,\"journal\":{\"name\":\"Nephrology Dialysis Transplantation\",\"volume\":\" \",\"pages\":\"320-328\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-02-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792657/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nephrology Dialysis Transplantation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ndt/gfae137\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"TRANSPLANTATION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nephrology Dialysis Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ndt/gfae137","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TRANSPLANTATION","Score":null,"Total":0}
Kidney failure from kidney stones: an ANZDATA study.
Background: Kidney stones are common, with an increasing trend over time, and have been well studied in the general population. However, the incidence and outcomes of kidney stones leading to kidney failure (KF) and the receipt of kidney replacement therapy (KRT) are poorly examined. We examined the incidence of KF due to kidney stones and compared outcomes with KRT patients due to other causes.
Methods: We studied adult patients who started KRT (January 1981-December 2020) and are included in the Australia and New Zealand Dialysis and Transplant (ANZDATA) registry. Exposure was KRT patients due to kidney stones, comparing them with patients with other causes. We examined incidence, prevalence, patient survival (KRT and transplant) and graft survival (transplant). Cox regression models were fitted to compare patient survival between the kidney stones and non-kidney stones groups, overall KRT, dialysis and patient and graft survival after kidney transplant.
Results: A total of 834 (1.1%) patients commenced KRT due to kidney stones. The incidence was 1.17 per million population per year and remained stable during the study period (annual change -0.3% [95% confidence interval (CI) -1.5-0.9]. Survival was higher in kidney stone patients receiving dialysis compared with the non-kidney stone group [hazard ratio (HR) 0.89 (95% CI 0.82-0.96)], with similar estimates in a matched cohort. In kidney transplant patients, time to transplant was longer for patients with kidney stones compared with non-kidney stone patients (2.5 versus 1.7 years; P = .001). There was no difference in mortality [HR 1.02 (95% CI 0.82-1.28)] or graft loss [HR 1.07 (95% CI 0.79-1.45)] between the kidney stones and non-kidney stones patients in the kidney transplant group.
Conclusion: The incidence of KF due to kidney stones was unchanged over the study period. Survival of patients with kidney stones who require KRT was better compared with patients with other causes. For the kidney transplant group, survival and risk of graft failure were similar.
期刊介绍：
Nephrology Dialysis Transplantation (ndt) is the leading nephrology journal in Europe and renowned worldwide, devoted to original clinical and laboratory research in nephrology, dialysis and transplantation. ndt is an official journal of the [ERA-EDTA](http://www.era-edta.org/) (European Renal Association-European Dialysis and Transplant Association). Published monthly, the journal provides an essential resource for researchers and clinicians throughout the world. All research articles in this journal have undergone peer review.
Print ISSN: 0931-0509.
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