{"title":"头孢他啶在中枢神经系统和眼部感染中的应用：病例系列。","authors":"Emily A Siegrist, Joseph Sassine","doi":"10.1093/jacamr/dlae095","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There are limited data describing outcomes of patients treated with ceftaroline for infections with CNS or ocular involvement.</p><p><strong>Objectives: </strong>To describe outcomes of patients treated with ceftaroline for methicillin-resistant staphylococcal infections involving the CNS or eye.</p><p><strong>Patients and methods: </strong>This was a retrospective review of 10 patients at an academic medical centre who received ceftaroline for CNS or ocular infections.</p><p><strong>Results: </strong>All patients were treated with ceftaroline as part of a combination for salvage therapy. Four patients died, whereas six patients experienced clinical cure. Only one experienced microbiological recurrence.</p><p><strong>Conclusions: </strong>These preliminary data suggest that ceftaroline may be an option for salvage therapy of severe staphylococcal infections when used in combination.</p>","PeriodicalId":14594,"journal":{"name":"JAC-Antimicrobial Resistance","volume":null,"pages":null},"PeriodicalIF":3.7000,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180797/pdf/","citationCount":"0","resultStr":"{\"title\":\"Ceftaroline in CNS and ocular infections: a case series.\",\"authors\":\"Emily A Siegrist, Joseph Sassine\",\"doi\":\"10.1093/jacamr/dlae095\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There are limited data describing outcomes of patients treated with ceftaroline for infections with CNS or ocular involvement.</p><p><strong>Objectives: </strong>To describe outcomes of patients treated with ceftaroline for methicillin-resistant staphylococcal infections involving the CNS or eye.</p><p><strong>Patients and methods: </strong>This was a retrospective review of 10 patients at an academic medical centre who received ceftaroline for CNS or ocular infections.</p><p><strong>Results: </strong>All patients were treated with ceftaroline as part of a combination for salvage therapy. Four patients died, whereas six patients experienced clinical cure. Only one experienced microbiological recurrence.</p><p><strong>Conclusions: </strong>These preliminary data suggest that ceftaroline may be an option for salvage therapy of severe staphylococcal infections when used in combination.</p>\",\"PeriodicalId\":14594,\"journal\":{\"name\":\"JAC-Antimicrobial Resistance\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11180797/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JAC-Antimicrobial Resistance\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/jacamr/dlae095\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JAC-Antimicrobial Resistance","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/jacamr/dlae095","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Ceftaroline in CNS and ocular infections: a case series.
Background: There are limited data describing outcomes of patients treated with ceftaroline for infections with CNS or ocular involvement.
Objectives: To describe outcomes of patients treated with ceftaroline for methicillin-resistant staphylococcal infections involving the CNS or eye.
Patients and methods: This was a retrospective review of 10 patients at an academic medical centre who received ceftaroline for CNS or ocular infections.
Results: All patients were treated with ceftaroline as part of a combination for salvage therapy. Four patients died, whereas six patients experienced clinical cure. Only one experienced microbiological recurrence.
Conclusions: These preliminary data suggest that ceftaroline may be an option for salvage therapy of severe staphylococcal infections when used in combination.
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