婴儿特应性皮炎发育过程中的皮肤屏障和微生物群:皮肤护理能预防发病吗?

IF 4.8 4区 医学 Q2 IMMUNOLOGY
Tomoka Ito, Yuumi Nakamura
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引用次数: 0

摘要

特应性皮炎(AD)是一种流行的 Th2 主导型皮肤病,涉及复杂的遗传和环境因素,包括 Filaggrin 基因突变和以金黄色葡萄球菌增多为特征的皮肤微生物群失调。我们最近的研究结果强调了皮肤屏障的完整性和微生物组成在婴儿 AD 和过敏性疾病中的关键作用。早期皮肤菌群失调容易导致婴儿过敏性鼻炎,这表明有针对性的护肤方法是一种预防策略。护肤干预的效果,尤其是使用含有适当摩尔浓度神经酰胺、胆固醇和脂肪酸的保湿剂,对恢复皮肤屏障起着至关重要的作用。值得注意的是,我们的研究表明,适当的护肤品可以减少链球菌的数量,同时支持痤疮棒状杆菌的存在,从而将护肤方法与新生儿皮肤的微生物调节直接联系起来。尽管之前的随机对照试验对保湿剂在预防AD方面的功效结果不一,但我们的研究表明,护肤干预可最大限度地减少遗传和环境因素的影响,从而有可能成为预防AD的主要方法。此外,我们的研究还支持这样一种观点,即早期积极治疗湿疹可降低食物过敏的发病率,这突出说明了同时解决皮肤屏障和免疫致敏问题的多方面预防策略的必要性。通过关注从出生开始修复皮肤屏障和调整皮肤的微生物群,我们提出了预防婴幼儿AD和过敏性疾病的新观点,为过敏预防的未来研究和实践开辟了新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The skin barrier and microbiome in infantile atopic dermatitis development: can skincare prevent onset?

Atopic dermatitis (AD), a prevalent Th2-dominant skin disease, involves complex genetic and environmental factors, including mutations in the Filaggrin gene and dysbiosis of skin microbiota characterized by an increased abundance of Staphylococcus aureus. Our recent findings emphasize the pivotal role of the skin barrier's integrity and microbial composition in infantile AD and allergic diseases. Early skin dysbiosis predisposes infants to AD, suggesting targeted skincare practices as a preventive strategy. The effects of skincare interventions, particularly the application of moisturizers with the appropriate molar concentration of ceramides, cholesterol, and fatty acids, play a crucial role in restoring the skin barrier. Notably, our study revealed that appropriate skincare can reduce Streptococcus abundance while supporting Cutibacterium acnes presence, thus directly linking skincare practices to microbial modulation in neonatal skin. Despite the mixed outcomes of previous Randomized Controlled Trials on the efficacy of moisturizers in AD prevention, our research points to the potential of skincare intervention as a primary preventive method against AD by minimizing the impact of genetic and environmental factors. Furthermore, our research supports the notion that early aggressive management of eczema may reduce the incidence of food allergies, highlighting the necessity for multifaceted prevention strategies that address both the skin barrier and immune sensitization. By focusing on repairing the skin barrier and adjusting the skin's microbiome from birth, we propose a novel perspective on preventing infantile AD and allergic diseases, opening new avenues for future studies, and practices in allergy prevention.

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来源期刊
International immunology
International immunology 医学-免疫学
CiteScore
9.30
自引率
2.30%
发文量
51
审稿时长
6-12 weeks
期刊介绍: International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.
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