骨骼肌固定诱发的萎缩:人体研究的机理启示。

IF 6.7 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Colleen S Deane, Matthew Piasecki, Philip J Atherton
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引用次数: 0

摘要

骨骼肌废用期导致肌肉质量迅速下降(萎缩),其根本原因是肌肉蛋白质合成(MPS)和肌肉蛋白质分解(MPB)之间的不平衡。人们研究了导致肌肉蛋白平衡在废用过程中发生改变的分子机制的复杂相互作用,但很少以人类为背景进行综合分析。这篇叙述性综述讨论了肌肉废用和随之而来的反指数肌肉萎缩率的人体模型。文章探讨了导致蛋白质平衡改变的分子过程,尤其关注生长和分解信号通路、线粒体适应性和神经肌肉功能障碍。最后,强调了废用性肌萎缩文献中的主要研究空白,为我们今后从机理角度进一步了解人类废用性肌萎缩提供了途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Skeletal muscle immobilisation-induced atrophy: mechanistic insights from human studies.

Periods of skeletal muscle disuse lead to rapid declines in muscle mass (atrophy), which is fundamentally underpinned by an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). The complex interplay of molecular mechanisms contributing to the altered regulation of muscle protein balance during disuse have been investigated but rarely synthesised in the context of humans. This narrative review discusses human models of muscle disuse and the ensuing inversely exponential rate of muscle atrophy. The molecular processes contributing to altered protein balance are explored, with a particular focus on growth and breakdown signalling pathways, mitochondrial adaptations and neuromuscular dysfunction. Finally, key research gaps within the disuse atrophy literature are highlighted providing future avenues to enhance our mechanistic understanding of human disuse atrophy.

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来源期刊
Clinical science
Clinical science 医学-医学:研究与实验
CiteScore
11.40
自引率
0.00%
发文量
189
审稿时长
4-8 weeks
期刊介绍: Translating molecular bioscience and experimental research into medical insights, Clinical Science offers multi-disciplinary coverage and clinical perspectives to advance human health. Its international Editorial Board is charged with selecting peer-reviewed original papers of the highest scientific merit covering the broad spectrum of biomedical specialities including, although not exclusively: Cardiovascular system Cerebrovascular system Gastrointestinal tract and liver Genomic medicine Infection and immunity Inflammation Oncology Metabolism Endocrinology and nutrition Nephrology Circulation Respiratory system Vascular biology Molecular pathology.
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