印度比哈尔邦 COVID-19 患者唾液、粪便和尿液样本中 SARS-CoV-2 病毒的流行情况

Access Microbiology Pub Date : 2024-06-01 DOI:10.1099/acmi.0.000693.v4

Nupur Meghna, Archana Archana, D. Bhushan, Abhyuday Kumar, A. Sarfraz, B. Naik, B. Pati

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引用次数: 0

摘要

导言由 SARS-CoV-2 引起的冠状病毒疾病可导致多个器官受累，严重程度不一。除吸入传播途径外，粪口传播也被提出。它传播到污水系统是一个日益严重的公共卫生问题。目标：检测 SARS-CoV-2检测比哈尔邦 COVID-19 病例非呼吸道样本（唾液、尿液和粪便）中的 SARS-CoV-2 RNA。方法这项横断面观察性研究于 2021 年 1 月至 2022 年 3 月对人类非呼吸道样本进行了检测。共从 143 例 COVID-19 病例中采集了 345 份样本，包括唾液（116 份）、粪便（97 份）和尿液（132 份）。通过针对 E、ORF 1ab 和 RdRp 基因的多重 RT-PCR 技术对样本进行了 SARS-CoV-2 分析。研究结果在 143 例病例中，共有 107 例（74.8%）的非呼吸道样本中至少有一个样本的 SARS-CoV-2 RNA 呈阳性。研究结论非呼吸道样本中 SARS-CoV-2 病毒的流行率很高。

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Prevalence of SARS-CoV-2 virus in saliva, stool, and urine samples of COVID-19 patients in Bihar, India

Introduction. The coronavirus illness caused by SARS-CoV-2 can cause multiple organ involvement, with varying degrees of severity. Besides inhalation as a route for transmission, feco-oral has also been proposed. Its transmission to sewage systems is a growing public health issue. Objective. To detect SARS-CoV-2 RNA in non-respiratory samples (saliva, urine, and stool) collected from COVID-19 cases, in Bihar. Methods. This cross-sectional observational study was conducted from January 2021 to March 2022 on human non-respiratory samples. A total of 345 samples including saliva (116), stool (97), and urine (132) were collected from 143 COVID-19 cases. Samples were analysed for SARS-CoV-2 by multiplex RT-PCR targeted against E, ORF 1ab, and RdRp genes. Results. In this study, out of 143 cases, a total of 107 (74.8 %) were positive for SARS-CoV-2 RNA in at least one of the non-respiratory samples. Conclusion. There is a high prevalence of SARS-CoV-2 virus in non-respiratory samples.

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