利用铃木偶联反应并用正丁基锂处理从四氯乙烯制备二苯基乙炔的简明合成路线

IF 1.4 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Letters Pub Date : 2024-06-01 DOI:10.1093/chemle/upae043

Yuta Fujiki, Hiyono Suzuki, Junya Kikuzawa, Keiji Nishiwaki, N. Kawashita, Junpei Matsuoka, Akira Nakamura, Tomohiro Maegawa, Akiko Kuwabara, Masafumi Kobayashi, Kouichi Matsumoto

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引用次数: 0

摘要

我们希望报告一种新的二苯基乙炔合成方法：在 Pd 催化剂存在下，四氯乙烯与苯硼酸发生反应，然后通过一个加工过程得到粗产物，再通过 Cl 原子的卤素锂交换以及 Li 原子和 Cl 原子的损失，使其与正丁基锂发生反应，从而以良好的收率得到所需的二苯基乙炔。

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Concise synthetic routes for diphenylacetylene from tetrachloroethylene using Suzuki coupling reaction followed by treatment with n-butyllithium

We wish to report a new synthetic approach for diphenylacetylene in which tetrachloroethylene was reacted with phenylboronic acid in the presence of Pd catalyst, followed by a workup procedure to provide the crude product, which was then allowed to react with n-butyllithium via the halogen lithium exchange of Cl atom and loss of Li and Cl atoms to afford the desired diphenylacetylene in good yield.

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来源期刊

Chemistry Letters 化学-化学综合

CiteScore

3.00

自引率

6.20%

发文量

260

审稿时长

1.2 months

期刊介绍： Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry