Pauline Balder , Celine Jones , Kevin Coward , Marc Yeste
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Moreover, numerous endogenous and exogenous factors are known to affect sperm chromatin, which may in turn impact the reproductive success. Concerns have been raised about the effects of assisted reproductive technology (ART) on the sperm epigenome, embryonic development and offspring health. This review examines the structure and epigenetic signatures of sperm chromatin in the context of fertility and early embryonic development. Additionally, sperm chromatin evaluation and causes of aberrant integrity are outlined. Building on the knowledge discussed in the current review, future research should aim to elucidate the intricate relationship between all aspects of sperm chromatin and embryo development. This could lead to the uncovering of new targets for treating infertility, as well as the acquisition of much needed insights into the possible reciprocal association between ART and sperm chromatin integrity.</p></div>","PeriodicalId":12010,"journal":{"name":"European journal of cell biology","volume":"103 3","pages":"Article 151429"},"PeriodicalIF":4.3000,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0171933524000463/pdfft?md5=b59b83b2b7f9a4a42708cb232813d86c&pid=1-s2.0-S0171933524000463-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Sperm chromatin: Evaluation, epigenetic signatures and relevance for embryo development and assisted reproductive technology outcomes\",\"authors\":\"Pauline Balder , Celine Jones , Kevin Coward , Marc Yeste\",\"doi\":\"10.1016/j.ejcb.2024.151429\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Sperm chromatin is distinct from somatic cell chromatin, as a result of extensive remodeling during the final stages of spermatogenesis. 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引用次数: 0
摘要
精子染色质有别于体细胞染色质,这是精子发生最后阶段广泛重塑的结果。在这一过程中,大部分组蛋白被原胺取代。因此,染色质高度浓缩且具有惰性,有利于保护 DNA。组蛋白保留、组蛋白和原胺修饰、DNA 甲基化以及 RNA 等因素决定了精子的表观基因组结构。近年来,对精子染色质完整性及其表观遗传标记的研究日益增多,精子染色质的构成也在不断被揭示。越来越多的研究促使人们对精子在生育和胚胎发育过程中经常被忽视的参与进行评估。此外,已知许多内源性和外源性因素会影响精子染色质,进而影响生殖成功率。辅助生殖技术(ART)对精子表观基因组、胚胎发育和后代健康的影响引起了人们的关注。本综述从生育力和早期胚胎发育的角度研究了精子染色质的结构和表观遗传特征。此外,还概述了精子染色质的评估和导致染色质完整性异常的原因。在本综述所讨论的知识基础上,未来的研究应致力于阐明精子染色质的各个方面与胚胎发育之间错综复杂的关系。这将有助于发现治疗不孕不育症的新靶点,并对 ART 与精子染色质完整性之间可能存在的相互关系获得亟需的深入了解。
Sperm chromatin: Evaluation, epigenetic signatures and relevance for embryo development and assisted reproductive technology outcomes
Sperm chromatin is distinct from somatic cell chromatin, as a result of extensive remodeling during the final stages of spermatogenesis. In this process, the majority of histones is replaced with protamines. The chromatin is consequently highly condensed and inert, which facilitates protection of the DNA. The sperm epigenomic landscape is shaped by histone retention, histone and protamine modification, DNA methylation, and RNAs. In recent years, sperm chromatin integrity and its epigenetic marks have been increasingly studied, and the constitution of sperm chromatin is steadily being uncovered. This growing body of research prompts assessment of the frequently overlooked involvement of sperm in fertility and embryonic development. Moreover, numerous endogenous and exogenous factors are known to affect sperm chromatin, which may in turn impact the reproductive success. Concerns have been raised about the effects of assisted reproductive technology (ART) on the sperm epigenome, embryonic development and offspring health. This review examines the structure and epigenetic signatures of sperm chromatin in the context of fertility and early embryonic development. Additionally, sperm chromatin evaluation and causes of aberrant integrity are outlined. Building on the knowledge discussed in the current review, future research should aim to elucidate the intricate relationship between all aspects of sperm chromatin and embryo development. This could lead to the uncovering of new targets for treating infertility, as well as the acquisition of much needed insights into the possible reciprocal association between ART and sperm chromatin integrity.
期刊介绍:
The European Journal of Cell Biology, a journal of experimental cell investigation, publishes reviews, original articles and short communications on the structure, function and macromolecular organization of cells and cell components. Contributions focusing on cellular dynamics, motility and differentiation, particularly if related to cellular biochemistry, molecular biology, immunology, neurobiology, and developmental biology are encouraged. Manuscripts describing significant technical advances are also welcome. In addition, papers dealing with biomedical issues of general interest to cell biologists will be published. Contributions addressing cell biological problems in prokaryotes and plants are also welcome.