欧洲原发性小儿低级别胶质瘤标准临床实践建议

Kleoniki Roka , Katrin Scheinemann , Shivaram Avula , John H. Maduro , Ulrich W. Thomale , Astrid Sehested , A.Y.N. Schouten-Van Meeteren , on behalf of the interdisciplinary SIOPe LGG Working Group
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引用次数: 0

摘要

小儿低级别胶质瘤是儿童和青少年时期最常见的脑肿瘤。尽管预后良好,但小儿低级别胶质瘤幸存者可能会出现不同程度的长期并发症,并可能需要反复治疗,这意味着这是一种慢性疾病。本综述介绍了初诊低级别胶质瘤的欧洲标准临床实践建议,该建议是在欧洲参考网络PaedCan的框架内代表SIOPe BTG LGG工作组制定的。手稿介绍了儿科低级别胶质瘤的不同类型,包括位置、年龄、潜在的癌症易感综合征和特殊情况,如婴儿脊索下丘脑胶质瘤和间脑综合征,以及当前的诊断标准和治疗适应症。此外,它还提供了组织病理学和分子病理学方面的最新知识。最后,该综述重点介绍了多学科方法的必要性和治疗适应症,提供了目前的治疗模式指南,在欧洲被用作一线疗法,并提供了不良反应和随访信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
European standard clinical practice recommendations for primary pediatric low-grade gliomas

Pediatric low-grade gliomas are the most common brain tumours in childhood and adolescence. Despite the excellent prognosis, pediatric low-grade glioma survivors may suffer from variable long-term complications and may require repeated therapies, implying that this is a chronic disease. The current review describes the European Standard Clinical Practice recommendations for low-grade gliomas at primary diagnosis, that were developed on behalf of SIOPe BTG LGG Working Group within the framework of European Reference Network PaedCan. The manuscript describes the diverse spectrum of pediatric low-grade gliomas in terms of location, age, underlying cancer predisposition syndromes, and special circumstances, such as infantile chiasmatic hypothalamic glioma and diencephalic syndrome, as well as current diagnostic criteria and indications for treatment. Furthermore, it provides current knowledge in histopathology and molecular pathology. Finally, the review focuses on the need for a multidisciplinary approach and treatment indications providing a guide on current treatment modalities, used as first-line therapy in Europe along with information on adverse effects, and follow-up.

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