地高辛可以治疗严重甲基黄嘌呤过量引起的快速性心律失常吗？

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-06-12 DOI:10.1016/j.mehy.2024.111408

Prinay Sohal , Michael E. Mullins

{"title":"地高辛可以治疗严重甲基黄嘌呤过量引起的快速性心律失常吗？","authors":"Prinay Sohal , Michael E. Mullins","doi":"10.1016/j.mehy.2024.111408","DOIUrl":null,"url":null,"abstract":"<div><p>Caffeine and theophylline use can lead to methylxanthine toxicity, resulting in life-threatening tachyarrhythmias and hypotension. Esmolol, a beta-adrenergic antagonist, is a suggested option for controlling associated tachyarrhythmias. However, esmolol is not universally available, and its hypotensive effects often deter its use. Digoxin, another rate control agent which is widely available, theoretically possesses the circulatory system effects needed to tackle both tachyarrhythmia and hypotension induced by methylxanthine toxicity. We propose digoxin as an alternative to esmolol, especially in regions where esmolol is unavailable and for individuals experiencing hypotension due to methylxanthine toxicity.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"189 ","pages":"Article 111408"},"PeriodicalIF":2.1000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?\",\"authors\":\"Prinay Sohal , Michael E. Mullins\",\"doi\":\"10.1016/j.mehy.2024.111408\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Caffeine and theophylline use can lead to methylxanthine toxicity, resulting in life-threatening tachyarrhythmias and hypotension. Esmolol, a beta-adrenergic antagonist, is a suggested option for controlling associated tachyarrhythmias. However, esmolol is not universally available, and its hypotensive effects often deter its use. Digoxin, another rate control agent which is widely available, theoretically possesses the circulatory system effects needed to tackle both tachyarrhythmia and hypotension induced by methylxanthine toxicity. We propose digoxin as an alternative to esmolol, especially in regions where esmolol is unavailable and for individuals experiencing hypotension due to methylxanthine toxicity.</p></div>\",\"PeriodicalId\":18425,\"journal\":{\"name\":\"Medical hypotheses\",\"volume\":\"189 \",\"pages\":\"Article 111408\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical hypotheses\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306987724001518\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical hypotheses","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306987724001518","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

使用咖啡因和茶碱会导致甲基黄嘌呤中毒，引起快速性心律失常和低血压，危及生命。Esmolol 是一种β-肾上腺素能拮抗剂，建议用于控制相关的快速性心律失常。然而，艾司洛尔并不是普遍可用的药物，而且其降压作用往往会阻碍其使用。地高辛是另一种可广泛获得的心率控制药物，理论上具有解决甲基黄嘌呤毒性引起的快速性心律失常和低血压所需的循环系统效应。我们建议将地高辛作为艾司洛尔的替代药物，尤其是在无法获得艾司洛尔的地区，以及因甲基黄嘌呤中毒而出现低血压的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Could digoxin treat tachyarrhythmias in severe methylxanthine overdose?

Caffeine and theophylline use can lead to methylxanthine toxicity, resulting in life-threatening tachyarrhythmias and hypotension. Esmolol, a beta-adrenergic antagonist, is a suggested option for controlling associated tachyarrhythmias. However, esmolol is not universally available, and its hypotensive effects often deter its use. Digoxin, another rate control agent which is widely available, theoretically possesses the circulatory system effects needed to tackle both tachyarrhythmia and hypotension induced by methylxanthine toxicity. We propose digoxin as an alternative to esmolol, especially in regions where esmolol is unavailable and for individuals experiencing hypotension due to methylxanthine toxicity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.