Association between glycated hemoglobin index and triglycerides-glucose index in a sample of non-diabetic individuals and its relation with insulin resistance

Introduction: Studies have shown that elevations of the triglyceride/glucose index (TyG) as well as the glycation of hemoglobin index (HGI) are associated with several complications related to insulin resistance (IR). Objective: To evaluate the association between HGI and TyG index in a sample of non-diabetic individuals and it’s relation with IR. Method: A cross-sectional study was conducted with 32 non-diabetic individuals. The variables analyzed included age, gender, body mass index, and laboratory data (triglycerides, glucose, HbA1c, and insulin). We calculated the TyG index, HOMA-IR, and HGI. Simple and multivariate linear regression analyses were also performed, in addition to ANOVA and Pearson's correlation between variables. Results: The multivariate linear regression analysis of the analyzed sample revealed a significant correlation between the TyG index and HGI, which was confirmed by the T-test. The results indicated a strong positive correlation between the TyG index and HGI, with a Pearson correlation coefficient of 0.98. Conclusion: The HGI, TyG index and IR showed a significant association in the analyzed sample. This suggests that both indices are highly reliable in measuring IR and glucose metabolism and may be markers of risk independent of fasting plasma glucose, and the other variables evaluated in this study.