Effect of Dangke on Changes in Neutrophil to Lymphocyte Ratio in Obese White Rats

Introduction: Obesity is associated with inflammation. Previous research has found that obesity determined by Body Mass Index (BMI) and Waist Circumference (LP) is associated with inflammation. Dangke contains Indigenos Lactic Acid Bacteria. The presence of lactic acid bacteria in fermented products has very positive benefits for health. The function of papaya sap which is used in making dangke, can act as an antibacterial and anti-inflammatory ingredient. Methods: Pure experimental research with a design, namely Pre-Post Randomized Clinical Trial Design. Data analysis used the independent T-test/Mann-Whitney test with a value <0.05. Results: The difference in the mean levels of Neutrophil to Lymphocyte (NLR) in the Intervention and control groups obtained a p-value of 0.94 which means that there is no relationship between control and intervention on NLR levels. The average change in NLR levels in the control group p-value of 0.61 which means there is no significant change in NLR levels in test 1 and test 2. The average change in NLR levels in the intervention group before and after the intervention was given a p-value of 0.07, which means there was no significant change in NLR levels in the intervention group. Conclusion: This study showed that intervention with Dangke did not yield a significant alteration in the NLR levels within the animal model of obesity.