调整化疗剂量和延迟化疗对运动的白血病和淋巴瘤患者的影响

Bartłomiej Szymański, Szymon Piaszczyński, Kacper Płeska, Joanna Wojtania, Michał Łepik, Zofia Uszok, Krzysztof Rosiak, Kacper Reguła, Kamil Waloch, Andrzej Czajka
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摘要

本综述探讨了白血病和淋巴瘤所面临的严峻挑战,深入研究了流行病学、坚持治疗、体育锻炼的影响以及对更有效化疗方案的迫切需求。目的是综合现有知识,突出现有差距,并强调创新患者护理策略的重要性。流行病学数据显示了发病率的变化,并强调了年龄、遗传和生活方式在疾病风险和进展中的作用。这些见解对于有效预防和及时干预至关重要。讨论的重点是化疗方案的制定。根据个人的基因和癌症特征制定化疗方案可显著提高疗效,最大限度地减少不必要的副作用,从而改善患者的生活质量和依从性。坚持治疗是取得成功结果的基础,需要多方面的支持策略。教育、副作用管理和解决护理障碍是确保患者从治疗中充分获益的关键。化疗方案的个性化制定是当前的重点,旨在最大限度地提高疗效,同时减少副作用,以提高生活质量和生存率。结论主张采用研究与临床实践相结合的综合方法,以满足恶性肿瘤和患者的生物复杂性。这些领域的进展预示着未来个性化、有效、体贴的癌症治疗将成为常态,推动我们向将癌症转化为可控疾病的目标迈进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
impact of chemotherapy dose adjustment and delay in patients with leukemias and lymphomas who exercise
This review addresses the critical challenge of leukemia and lymphoma, delving into the epidemiology, treatment adherence, impact of physical activity, and the pressing need for more effective chemotherapy protocols. The purpose is to synthesize current knowledge, highlight existing gaps, and emphasize the importance of innovation in patient care strategies. Epidemiological data show variability in incidence rates and underscore the roles age, genetics, and lifestyle play in disease risk and progression. These insights are vital for effective prevention and timely intervention. The focus of the discussion revolves around the development of chemotherapy protocols. Tailoring these to the individual's genetic and cancer profile can lead to significant gains in efficacy and minimize unwanted side effects, crucially improving patient quality of life and compliance. Treatment adherence is fundamental to successful outcomes, requiring multifaceted support strategies. Education, side-effect management, and addressing care barriers are pivotal in ensuring patients fully benefit from therapy. Personalization in chemotherapy protocol development is a current focus, aiming to maximize efficacy while minimizing side effects to improve quality of life and survival. The conclusion advocates for an integrated approach combining research and clinical practice to cater to the biological intricacies of both the malignancy and the patient. Progress in these areas proclaims a future where personalized, effective, and compassionate cancer treatment is the norm, pushing us closer to the goal of transforming cancer into a manageable condition. 
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