使用 A 型肉毒杆菌毒素预防手术后肥厚性瘢痕和瘢痕疙瘩的前景（Meta 分析）

Pub Date : 2024-06-05 DOI:10.1055/s-0044-1787175

Natalia Korableva, Nikolay Romanenkov, Dmitriy Kremlev, Andrei Nekrasov, Maksim Miroshnichenko, Peter Arbekov

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引用次数: 0

摘要

摘要目的评估使用 A 型肉毒毒素（BTA）改善和预防术后增生性瘢痕和瘢痕疙瘩形成的可能性。材料与方法在 PubMed/MEDLINE 数据库中系统地筛选了整个期间发表的英文科学文章。分析了研究的以下信息：第一作者姓氏、发表年份、患者人数、平均年龄、疤痕位置、用药剂量、随访时间、疤痕评估方法、结果、增生性疤痕和瘢痕疙瘩形成的发生率。计算了每个估计参数的几率比例和 95% 的置信区间。采用卡方检验和 I 2 标准对出版物的统计异质性进行了评估。当 P < 0.05 时，差异被认为是显著的。结果共选取了 18 项前瞻性随机研究进行评估，其中包含 363 例使用 BTA 的数据。接受肉毒杆菌毒素治疗的患者的温哥华疤痕量表指数较低，视觉模拟量表指数较高，石溪疤痕评估量表评分较高。使用肉毒杆菌毒素可降低明显疤痕形成的风险，减少增生性疤痕和瘢痕疙瘩的发生率。结论使用 BTA 可获得不易察觉的疤痕，防止术后疤痕增生和瘢痕疙瘩，前景良好。然而，关于 BTA 对预防增生性疤痕和瘢痕疙瘩产生积极影响的病理生理机制，目前尚未达成共识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prospects for Use of Botulinum Toxin Type A for Prevention of Hypertrophic and Keloid Scars after Surgeries (Meta-analysis)

Abstract Objective To evaluate the possibility of improving and preventing the formation of postoperative hypertrophic and keloid scars using botulinum toxin type A (BTA). Materials and Methods Scientific articles published in English have been systematically screened in PubMed/MEDLINE database over the entire period. The following information about the studies was analyzed: first author surname; year of publication; number of patients; average age; scar location; dosage of the drug administered; follow-up duration; scar assessment methods; results, incidence of hypertrophic and keloid scars formation. The odds ratio and 95% confidence interval were calculated for each of the estimated parameters. The statistical heterogeneity of publications assessed using the criteria of chi-square test and I 2 . The differences were considered significant at p < 0.05. Results A total of 18 prospective randomized studies were selected for evaluation, containing data on the use of BTA in 363 cases. Patients receiving botulinum toxin had a lower Vancouver scar scale index, higher visual analog scale index, and higher Stony Brook scar evaluation scale score. The use of BTA reduces the risk of perceptible scar formation, the incidence of hypertrophic and keloid scars. Conclusion The use of BTA to obtain imperceptible scar and prevent hypertrophic and keloid postoperative scars demonstrates good prospects. However, there is no consensus regarding the pathophysiological mechanisms underlying the positive effect of BTA on the prevention of hypertrophic and keloid scars.

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