血管性痴呆存在吗?通过脑室-心房分流术治疗两例既往诊断为血管性痴呆的病例报告

Hari K. Garachetla, Kiyoshi Takagi, Ryosuke Takagi, Yoko Kato
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摘要

摘要 血管性痴呆(VaD)是仅次于阿尔茨海默病的第二大痴呆病因。虽然阿尔茨海默病已经有了新的治疗方法,但血管性痴呆目前还没有有效的治疗方法。我们遇到过两例认知功能障碍患者,他们在接受脑室-心房分流术(VA 分流术)后认知功能恢复到了正常水平。两例患者均在脑梗塞后不久出现认知功能障碍。他们的大脑图像显示脑室扩张,但没有发现蛛网膜下腔不成比例扩大的脑积水,而这被认为是特发性正常压力脑积水(iNPH)的特征。这两个病例最初都被神经外科医生诊断为 VaD。然而,由于他们对腰椎拍击试验呈阳性反应,因此进行了 VA 分流。两个病例的认知功能都恢复到了正常水平。VA分流术后,他们的认知功能得到了很好的恢复,这表明许多患有腔隙性脑梗塞的iNPH患者可能被误诊为VaD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does Vascular Dementia Exist? Report of Two Cases Previously Diagnosed with Vascular Dementia Treated by Means of Ventriculoatrial Shunts
Abstract Vascular dementia (VaD) is the second most common cause of dementia after Alzheimer's disease. While new therapeutic modalities have been available for Alzheimer's disease, there is currently no effective treatment for VaD. We encountered two cases with VaD who recovered their cognitive function to normal levels after ventriculoatrial shunt (VA shunt). Both cases complained cognitive impairment shortly after cerebral infarctions. Their brain images showed ventricular dilatation without the findings of disproportionately enlarged subarachnoid space hydrocephalus, which is regarded as characteristic for idiopathic normal pressure hydrocephalus (iNPH). Both cases were initially diagnosed as VaD by board neurosurgeons. However, since they showed positive response to lumbar tap test, VA shunts were performed. Both cases recovered their cognitive function to normal level. Their excellent cognitive outcomes after VA shunts indicate that many iNPH patients with lacunar infarcts may possibly be misdiagnosed as VaD.
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