巴布亚阿贝普拉医院艾滋病毒感染者中免疫反应缺失者的特征

J. Sembiring, A. Indrati, Widya Amalia
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摘要

感染人类免疫缺陷病毒(HIV)会降低人体的免疫系统,尤其是 CD4+ 细胞,从而更容易受到机会性感染。大约有 10-40% 的艾滋病毒/艾滋病感染者(PLHIV)在病毒持续抑制的情况下,CD4+ T 细胞仍无法达到正常水平,这种情况被称为免疫无反应者(INR)。以往的研究表明,免疫无应答者可通过各种免疫系统抑制机制预测接受抗逆转录病毒(ARV)治疗的艾滋病病毒感染者的病情发展,从而增加发病率和死亡率。巴布亚是艾滋病毒流行区,发病率为 2.3%。本研究是一项队列研究,于2019年6月至2023年2月在阿贝普拉医院进行,旨在确定影响接受抗逆转录病毒治疗的艾滋病毒感染者发生INR的因素。共有123名研究对象,其中INR组55人(44.7%),非INR组68人(55.3%)。结果显示,INR的发生率男性高于女性(P=0.019),INR与年龄增长显著相关(P=0.013),开始接受抗逆转录病毒治疗时CD4计数较低(P=0.002)。INR 和非 INR 之间的 CD4 细胞数存在明显差异(p<0.001)。作为一种常见的机会性感染,口腔念珠菌病在 INR 患者中比非 INR 患者更常见。(p=0.037).这项研究表明,有必要在开始治疗时进行 CD4 检查,并每 6 个月进行一次监测,以发现可能的 INR,从而防止艾滋病和非艾滋病风险的增加,因为后者会增加死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characteristics of Immunological Non-Responders in People Living with HIV at Abepura Hospital Papua
Infection of Human Immunodeficiency Virus (HIV) lowers the body's immune system, especially CD4+ cells, making it more susceptible to opportunistic infections. Approximately 10-40% of People Living with HIV/AIDS (PLHIV) fail to achieve normal levels of CD4+ T cells despite continued virological suppression, a condition called Immunological Non-Responders (INR). Previous studies have shown that INR is considered a predictor of disease progression in people with HIV receiving antiretroviral (ARV)s through various mechanisms of suppression of the immune system that increases morbidity and mortality. Papua is an HIV epidemic area with a prevalence of 2.3%. This research is a cohort study conducted at Abepura Hospital from June 2019 to February 2023, which aims to identify the factors that influence the occurrence of INR in PLHIV receiving ARV therapy. There were 123 research subjects consisting of 55 people (44.7%) in the INR group and 68 people (55.3%) in the non-INR group. The results showed that the incidence of INR was higher in males than females (p=0.019), INR was significantly associated with increasing age (p=0.013), and CD4 count was low at the start of ARVs (p=0.002). There was a significant difference in CD4 counts between INR and non-INR (p<0.001). Oral candidiasis as a common opportunistic infection is more common in people with INR than in non-INR. (p=0.037). This study suggested that it is necessary to carry out a CD4 examination at the start of therapy and monitoring every 6 months to detect possible INR to prevent an increased risk of AIDS and non-AIDS, which increases mortality.
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