Predictors for the Differentiation between Glioblastoma, Primary Central Nervous System Lymphoma, and Metastasis in Patients with a Solitary Enhancing Intracranial Mass

Abstract Introduction  Differentiation between glioblastoma (GBM), primary central nervous system lymphoma (PCNSL), and metastasis is important in decision-making before surgery. However, these malignant brain tumors have overlapping features. This study aimed to identify predictors differentiating between GBM, PCNSL, and metastasis. Materials and Methods  Patients with a solitary intracranial enhancing tumor and a histopathological diagnosis of GBM, PCNSL, or metastasis were investigated. All patients with intracranial lymphoma had PCNSL without extracranial involvement. Demographic, clinical, and radiographic data were analyzed to determine their associations with the tumor types. Results  The predictors associated with GBM were functional impairment ( p  = 0.001), large tumor size ( p  < 0.001), irregular tumor margin ( p  < 0.001), heterogeneous contrast enhancement ( p  < 0.001), central necrosis ( p  < 0.001), intratumoral hemorrhage ( p  = 0.018), abnormal flow void ( p  < 0.001), and hypodensity component on noncontrast cranial computed tomography (CT) scan ( p  < 0.001). The predictors associated with PCNSL comprised functional impairment ( p  = 0.005), deep-seated tumor location ( p  = 0.006), homogeneous contrast enhancement ( p  < 0.001), absence of cystic appearance ( p  = 0.008), presence of hypointensity component on precontrast cranial T1-weighted magnetic resonance imaging (MRI; p  = 0.027), and presence of isodensity component on noncontrast cranial CT ( p  < 0.008). Finally, the predictors for metastasis were an infratentorial ( p  < 0.001) or extra-axial tumor location ( p  = 0.035), smooth tumor margin ( p  < 0.001), and presence of isointensity component on cranial fluid-attenuated inversion recovery MRI ( p  = 0.047). Conclusion  These predictors may be used to differentiate between GBM, PCNSL, and metastasis, and they are useful in clinical management.