{"title":"利用紫外光谱测定纳米制剂中的白藜芦醇:强制降解和药物夹带","authors":"Bhavna Sonule, Nikhil Mehetre, Lalit Kumar","doi":"10.1515/tsd-2024-2595","DOIUrl":null,"url":null,"abstract":"Abstract Dietary polyphenols from plant sources play an important role in the human diet. They have various biological effects, such as protein kinase inhibition, antibacterial, anticancer, antiulcer, antiarthritic, and anti-angiogenic properties. Among the various phenolic chemicals found in plants, resveratrol (trans-3,5,4′-trihydroxystilbene) (RVT) is a non-flavonoid polyphenolic compound that has been extensively studied for its health-promoting advantages, including its anti-cancer, neuroprotective, anti-inflammatory, antioxidant, and cardio-protective activities. Considering its potential in pharmaceutical nanoformulations, a rapid, economical, sensitive, and robust UV spectrophotometric method was developed and validated. The proposed method was developed in phosphate buffer at pH 7.4 to estimate the RVT content in the pharmaceutical nanoformulation. The method was developed at a reported wavelength of 306 nm. The developed method was validated according to ICH Q2A (R1) guidelines and was applied for the estimation of RVT in prepared nanoformulations. The method showed exceptional linearity in the range of (1–6) μg mL−1 with a coefficient of determinant value of 0.9998. The study proves that the developed method is linear, precise, sensitive, robust, reproducible, and accurate. This method can be applied for the estimation of RVT in nanoformulations and other bulk dosage forms.","PeriodicalId":22258,"journal":{"name":"Tenside Surfactants Detergents","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Determination of resveratrol in nanoformulations using UV-spectroscopy: forced degradation and drug entrapment\",\"authors\":\"Bhavna Sonule, Nikhil Mehetre, Lalit Kumar\",\"doi\":\"10.1515/tsd-2024-2595\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract Dietary polyphenols from plant sources play an important role in the human diet. They have various biological effects, such as protein kinase inhibition, antibacterial, anticancer, antiulcer, antiarthritic, and anti-angiogenic properties. Among the various phenolic chemicals found in plants, resveratrol (trans-3,5,4′-trihydroxystilbene) (RVT) is a non-flavonoid polyphenolic compound that has been extensively studied for its health-promoting advantages, including its anti-cancer, neuroprotective, anti-inflammatory, antioxidant, and cardio-protective activities. Considering its potential in pharmaceutical nanoformulations, a rapid, economical, sensitive, and robust UV spectrophotometric method was developed and validated. The proposed method was developed in phosphate buffer at pH 7.4 to estimate the RVT content in the pharmaceutical nanoformulation. The method was developed at a reported wavelength of 306 nm. The developed method was validated according to ICH Q2A (R1) guidelines and was applied for the estimation of RVT in prepared nanoformulations. The method showed exceptional linearity in the range of (1–6) μg mL−1 with a coefficient of determinant value of 0.9998. The study proves that the developed method is linear, precise, sensitive, robust, reproducible, and accurate. This method can be applied for the estimation of RVT in nanoformulations and other bulk dosage forms.\",\"PeriodicalId\":22258,\"journal\":{\"name\":\"Tenside Surfactants Detergents\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2024-06-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tenside Surfactants Detergents\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1515/tsd-2024-2595\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tenside Surfactants Detergents","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1515/tsd-2024-2595","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Determination of resveratrol in nanoformulations using UV-spectroscopy: forced degradation and drug entrapment
Abstract Dietary polyphenols from plant sources play an important role in the human diet. They have various biological effects, such as protein kinase inhibition, antibacterial, anticancer, antiulcer, antiarthritic, and anti-angiogenic properties. Among the various phenolic chemicals found in plants, resveratrol (trans-3,5,4′-trihydroxystilbene) (RVT) is a non-flavonoid polyphenolic compound that has been extensively studied for its health-promoting advantages, including its anti-cancer, neuroprotective, anti-inflammatory, antioxidant, and cardio-protective activities. Considering its potential in pharmaceutical nanoformulations, a rapid, economical, sensitive, and robust UV spectrophotometric method was developed and validated. The proposed method was developed in phosphate buffer at pH 7.4 to estimate the RVT content in the pharmaceutical nanoformulation. The method was developed at a reported wavelength of 306 nm. The developed method was validated according to ICH Q2A (R1) guidelines and was applied for the estimation of RVT in prepared nanoformulations. The method showed exceptional linearity in the range of (1–6) μg mL−1 with a coefficient of determinant value of 0.9998. The study proves that the developed method is linear, precise, sensitive, robust, reproducible, and accurate. This method can be applied for the estimation of RVT in nanoformulations and other bulk dosage forms.
期刊介绍:
Tenside Surfactants Detergents offers the most recent results of research and development in all fields of surfactant chemistry, such as: synthesis, analysis, physicochemical properties, new types of surfactants, progress in production processes, application-related problems and environmental behavior. Since 1964 Tenside Surfactants Detergents offers strictly peer-reviewed, high-quality articles by renowned specialists around the world.