在咳嗽中心接受治疗的成人中,难治性和不明原因慢性咳嗽的发病率

Paweł Kukiełka, Katarzyna Moliszewska, K. Białek-Gosk, E. M. Grabczak, Marta Dąbrowska
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引用次数: 0

摘要

难治性和原因不明的慢性咳嗽(RCC;UCC)给临床带来了巨大挑战,损害了患者的生活质量;然而,RCC的准确定义仍然难以确定。因此,本研究旨在评估转诊到我们咳嗽中心的患者中RCC和UCC的患病率,并根据其定义分析RCC的患病率。这项前瞻性队列研究纳入了2018-2022年间在咳嗽门诊确诊的所有患者。根据咳嗽严重程度的减轻(viathe Visual Analogue Scale [VAS])和咳嗽相关生活质量的改善(viathe Leicester cough questionnaire [LCQ])来衡量治疗反应。RCC的定义是咳嗽持续严重,经过≥2次治疗后仍无改善或改善甚微(ΔVAS<30毫米),且咳嗽严重程度≥40/100毫米(VAS)。在接受慢性咳嗽治疗的201名患者中,只有3人(1.5%)被诊断为UCC。根据 RCC 的基本定义,166 名患者中有 51 人(30.7%)被确诊为 UCC。如果采用更严格的标准(持续剧烈咳嗽≥40毫米[VAS]、治疗反应不充分[VAS]减轻<30毫米、[LCQ]改善<1.5分),将有45名受试者(27.1%)被诊断为RCC。RCC是咳嗽门诊转诊患者中的常见病,其发病率因诊断标准不同而略有差异。因此,有必要明确常规治疗中使用的 RCC 定义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of refractory and unexplained chronic cough in adults treated in cough centre
Refractory and unexplained chronic cough (RCC; UCC) pose significant clinical challenges, impairing patients’ quality of life; however, defining RCC precisely remains elusive. Hence, this study aimed to assess RCC and UCC prevalence among patients referred to our cough centre and to analyse RCC prevalence relative to its definition.This prospective cohort study included all patients who were diagnosed at a cough clinic between 2018–2022. The response to therapy was measured based on the reduction in cough severity (viathe Visual Analogue Scale [VAS]) and improvement in cough-related quality of life (viathe Leicester cough questionnaire [LCQ]). RCC was defined as persistent cough severity, with none or minimal improvement (ΔVAS<30 mm) after ≥2 treatment attempts and cough severity ≥40/100 mm (VAS).Of 201 patients treated for chronic cough, only three (1.5%) were diagnosed with UCC. Among 166 patients monitored for therapy response, 71 (42.8%) experienced a cough severity reduction in VAS ≥30 mm, while 100 (60.2%) showed an improvement in LCQ ≥1.5 points.Based on the basic RCC definition, 51 of 166 patients (30.7%) were diagnosed. If applying stricter criteria (persistent severe cough ≥40 mm [VAS], insufficient therapy response <30 mm reduction [VAS], and <1.5 point improvement [LCQ]), RCC would be diagnosed in 45 subjects (27.1%).RCC is common in patients referred to cough clinics. The prevalence of RCC differs slightly depending on the diagnostic criteria. Therefore, it is necessary to clarify the definition of RCC used in routine practice.
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