Is It a Necessity to Revise Normal Level of Prostate-Specific Antigen in Patients with Chronic Kidney Disease?

Background: Typically, patients with decreased renal function exhibit elevated levels of certain tumor markers. Prostate-specific antigen (PSA), a glycoprotein antigen produced by the prostate gland's epithelial cells and a member of the tissue kallikrein family, is among them. Objectives: This study aimed to investigate the potential relationship between free and total PSA levels, glomerular filtration rate (GFR), and Body Mass Index (BMI) in patients with chronic kidney disease (CKD). Methods: This cross-sectional investigation included 152 male CKD patients who met the inclusion criteria. Following the initial patient visits and enrollment, levels of free and total PSA, serum creatinine, and serum total protein were measured. Subsequently, GFR was calculated for all patients using Cockcroft's formula. Statistical analysis was performed using SPSS software. Results: The mean age of the participants was 58.5 ± 17.6 years. Furthermore, there were inverse relationships observed between the mean levels of free and total PSA with GFR, BMI, and serum creatinine clearance. Conclusions: The study's findings reveal inverse relationships between free and total PSA levels and GFR and BMI. Therefore, renal dysfunction can significantly influence PSA levels.