纤维增强型蚕丝微针贴片在治疗糖尿病伤口感染中改善组织粘附性

IF 17.2 1区 工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Yixin Wang, Pengpeng Guan, Ruiyi Tan, Zhenghui Shi, Qing Li, Bitao Lu, Enling Hu, Weiwei Ding, Wenyi Wang, Bowen Cheng, Guangqian Lan, Fei Lu
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引用次数: 0

摘要

具有独特三维立体化学结构的微针(MNs)是组织固定和药物输送的合适候选材料。然而,现有的水凝胶微针在溶胀后机械性能较差,且需要复杂的制备过程,阻碍了其实际应用。因此,我们设计了含有表没食子儿茶素没食子酸酯的壳聚糖纤维增强丝纤维素 MN 补丁(SCEMN)。我们引入了甲酸-氯化钙体系来制造具有出色固有粘附性的水凝胶 MN,并加入壳聚糖纤维作为增强材料,增强了机械强度和粘度,从而提高了与组织的物理互锁性和保持形状的能力。插入力较低的 SCEMN 可牢固地粘附在猪皮肤上,最大分离力为 11.98 牛/平方厘米。此外,SCEMN 还具有出色的抗氧化和抗菌特性,能促进巨噬细胞从 M1 极化到 M2,与商业产品 Tegaderm™ 相比,它在体内糖尿病伤口修复方面表现出更优越的性能。这项研究是纤维增强型水凝胶 MNs 用于强力组织粘附的首次试验。我们的研究结果表明,这种创新方法对于推动 MN 技术的发展,增强组织粘附力和加速伤口愈合具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Fiber-Reinforced Silk Microneedle Patches for Improved Tissue Adhesion in Treating Diabetic Wound Infections

Fiber-Reinforced Silk Microneedle Patches for Improved Tissue Adhesion in Treating Diabetic Wound Infections

Microneedles (MNs) with unique three-dimensional stereochemical structures are suitable candidates for tissue fixation and drug delivery. However, existing hydrogel MNs exhibit poor mechanical properties after swelling and require complex preparation procedures, impeding their practical application. Hence, we engineered chitosan fiber-reinforced silk fibroin MN patches containing epigallocatechin gallate (SCEMN). A formic acid–calcium chloride system was introduced to fabricate hydrogel MNs with excellent inherent adhesion, and the incorporation of chitosan fiber as a reinforcing material enhanced mechanical strength and viscosity, thereby increasing the physical interlocking with tissue and the ability to maintain shape. The SCEMN with a lower insertion force firmly adhered to porcine skin, with a maximum detachment force of 11.98 N/cm2. Additionally, SCEMN has excellent antioxidant and antibacterial properties, facilitates macrophage polarization from M1 to M2, and demonstrates superior performance in vivo for diabetic wound repair compared with the commercial product Tegaderm™. This study represents the first trial of fiber-reinforced hydrogel MNs for robust tissue adhesion. Our findings underscore the significance of this innovative approach for advancing MN technology to enhance tissue adhesion and accelerate wound healing.

Graphical Abstract

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来源期刊
CiteScore
18.70
自引率
11.20%
发文量
109
期刊介绍: Advanced Fiber Materials is a hybrid, peer-reviewed, international and interdisciplinary research journal which aims to publish the most important papers in fibers and fiber-related devices as well as their applications.Indexed by SCIE, EI, Scopus et al. Publishing on fiber or fiber-related materials, technology, engineering and application.
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