Rh(III)催化的苯甲酰胺氧化还原中性 C-H 多氟烯化反应

Synthesis Pub Date : 2024-06-11 DOI:10.1055/a-2343-0676

Jia-Qiang Wu, Wei Lin, Yifei Qu, Mei Xie, Huixuan Zhu, Jinhui Hu, Zhuang Xiong, Jun Xu, Wenhua Chen

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引用次数: 0

摘要

氟化分子广泛应用于制药和农用化学品行业。含多氟烷基的化合物因其改变药物和生物活性分子活性的独特能力而受到越来越多的关注。在此，我们报告了一种高效的 Rh(III) 催化的多氟烯烃与苯甲酰胺的氧化还原中性 C-H 多氟烯烃化反应，该反应为获得多种多氟烯烃化的炔类化合物提供了一种多功能方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rh(III)-Catalyzed Redox-neutral C-H Multifluoroalkenylation of Benzamides

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Rh(III)-Catalyzed Redox-neutral C-H Multifluoroalkenylation of Benzamides

Fluorinated molecules are widely used in pharmaceutical and agrochemical industries. Multifluoroalkyl-containing compounds have attracted increasing attention for their unique ability to alter the activity of drugs and bioactive molecules. Herein, we report an efficient Rh(III)-catalyzed redox-neutral C-H multifluoroalkenylation of benzamides with multifluoroalkenes, which provides a versatile protocol for accessing a wide range of multifluoroalkenylated arenes.

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来源期刊

Synthesis

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